PXD058230 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis |
Description | Becn1 deficiency in the megakaryocytic lineage reduces sex hormone-binding globulin (SHBG), thus releasing testosterone into the blood and ultimately leading to increased bone mass and improved bone quality. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_04:59:44.807.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zhao Chen |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-11-25 06:11:15 | ID requested | |
⏵ 1 | 2025-05-07 04:59:45 | announced | |
Publication List
10.1038/s41413-025-00410-7; |
Li L, Zhao C, Zhang R, Wei W, Liu B, Dong J, Gao X, Zhang D, Wang X, Lu M, Zhang Y, Yu Y, Yuan N, Xu Y, Wang J, Fang Y, Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis. Bone Res, 13(1):32(2025) [pubmed] |
Keyword List
submitter keyword: Mouse, bone homeostasis,Beclin1 |
Contact List
Wang Jianrong |
contact affiliation | Soochow University |
contact email | jrwang@suda.edu.cn |
lab head | |
Zhao Chen |
contact affiliation | Soochow University |
contact email | czhao7@stu.suda.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058230 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058230
- Label: PRIDE project
- Name: Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis