PXD058204

PXD058204 is an original dataset announced via ProteomeXchange.

Title	Integrating multi-omics to reveal and validate key proteins, metabolites, and pathways of ASB14 affecting mitochondrial function in cardiomyocytes AC16
Description	To explore the effects of the ASB14 gene on changes in mitochondria-associated protein levels and signaling pathways, a proteomic analysis containing blank cell control, empty vector control, and AC16 stably transfected cell strain overexpressing the ASB14 was included in the subproject. By comparing protein expression profiles among AC16 cells transfected with pCDH-NC and pCDH-ASB14, a total of 1306 differential proteins were obtained in this study, of which 495 were up-regulated and 811 were down-regulated. These proteins were significantly enriched into 32 KEGG pathways, including linoleic acid metabolism. ASB14 overexpression may mediate the metabolic level of linoleic acid by regulating differential proteins and further affects mitochondrial OXPHOS activity in cardiomyocytes.
HostingRepository	iProX
AnnounceDate	2024-11-22
AnnouncementXML	Submission_2024-11-24_20:42:18.443.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Che Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-24 20:41:40	ID requested
⏵ 1	2024-11-24 20:42:18	announced

Dataset with its publication pending

submitter keyword: ASB14, Proteomics, Metabolomics, Heart failure, Cardiomyocyte mitochondrial function

Che Wang
contact affiliation	Henan Provincial People's Hospital
contact email	wangche10@163.com
lab head
Che Wang
contact affiliation	Henan Provincial People's Hospital
contact email	wangche10@163.com
dataset submitter

iProX dataset URI