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PXD058165

PXD058165 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNitro-oleic acid in a HFpEF two-hit mouse model of high fat diet and L-NAME
DescriptionHeart failure is a disease with increasing prevalence, while present treatment options, especially for heart failure with preserved ejection fraction (HFpEF), are inadequate. Hypertension and obesity-related metabolic dysfunctions are important risk factors for HFpEF development and progression. Nitro-oleic acid (NO2-OA) impacts metabolic processes by improving glucose tolerance and adipocyte function. We sought to unravel effects of NO2-OA on cardiac function. Mice were fed for 15 weeks with high fat diet combined with endothelial nitric oxide synthase inhibitor (L-NAME). During the last 4 weeks treatment with nitro-oleic acid or vehicle was administered via osmotic pumps. Finally mice were sacrificed, left ventricular tissue harvested, snapfrozen in liquid nitrogen and stored at -80°C until protein isolation.
HostingRepositoryPRIDE
AnnounceDate2025-03-18
AnnouncementXMLSubmission_2025-03-18_05:56:15.531.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD058165
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterCornelius Welke
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-22 02:36:48ID requested
12025-03-18 05:56:15announced
Publication List
10.6019/PXD058165;
Keyword List
submitter keyword: HFpEF,Mouse, Heart, HFD, NO2-OA
Contact List
Anna Klinke
contact affiliationHeart and Diabetes Center NRW, Bad Oeynhausen University Hospital of the Ruhr-Universität Bochum
contact emailaklinke@hdz-nrw.de
lab head
Cornelius Welke
contact affiliationAgnes Wittenborg Institute for translational Cardiovascular Research Clinic for General and Interventional Cardiology/ Angiology
contact emailcwelke@hdz-nrw.de
dataset submitter
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Dataset FTP location
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