PXD058165 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Nitro-oleic acid in a HFpEF two-hit mouse model of high fat diet and L-NAME |
Description | Heart failure is a disease with increasing prevalence, while present treatment options, especially for heart failure with preserved ejection fraction (HFpEF), are inadequate. Hypertension and obesity-related metabolic dysfunctions are important risk factors for HFpEF development and progression. Nitro-oleic acid (NO2-OA) impacts metabolic processes by improving glucose tolerance and adipocyte function. We sought to unravel effects of NO2-OA on cardiac function. Mice were fed for 15 weeks with high fat diet combined with endothelial nitric oxide synthase inhibitor (L-NAME). During the last 4 weeks treatment with nitro-oleic acid or vehicle was administered via osmotic pumps. Finally mice were sacrificed, left ventricular tissue harvested, snapfrozen in liquid nitrogen and stored at -80°C until protein isolation. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-18 |
AnnouncementXML | Submission_2025-03-18_05:56:15.531.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD058165 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Cornelius Welke |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-11-22 02:36:48 | ID requested | |
⏵ 1 | 2025-03-18 05:56:15 | announced | |
Publication List
Keyword List
submitter keyword: HFpEF,Mouse, Heart, HFD, NO2-OA |
Contact List
Anna Klinke |
contact affiliation | Heart and Diabetes Center NRW, Bad Oeynhausen University Hospital of the Ruhr-Universität Bochum |
contact email | aklinke@hdz-nrw.de |
lab head | |
Cornelius Welke |
contact affiliation | Agnes Wittenborg Institute for translational Cardiovascular Research
Clinic for General and Interventional Cardiology/ Angiology |
contact email | cwelke@hdz-nrw.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058165
- Label: PRIDE project
- Name: Nitro-oleic acid in a HFpEF two-hit mouse model of high fat diet and L-NAME