PXD058165

PXD058165 is an original dataset announced via ProteomeXchange.

Title	Nitro-oleic acid in a HFpEF two-hit mouse model of high fat diet and L-NAME
Description	Heart failure is a disease with increasing prevalence, while present treatment options, especially for heart failure with preserved ejection fraction (HFpEF), are inadequate. Hypertension and obesity-related metabolic dysfunctions are important risk factors for HFpEF development and progression. Nitro-oleic acid (NO2-OA) impacts metabolic processes by improving glucose tolerance and adipocyte function. We sought to unravel effects of NO2-OA on cardiac function. Mice were fed for 15 weeks with high fat diet combined with endothelial nitric oxide synthase inhibitor (L-NAME). During the last 4 weeks treatment with nitro-oleic acid or vehicle was administered via osmotic pumps. Finally mice were sacrificed, left ventricular tissue harvested, snapfrozen in liquid nitrogen and stored at -80°C until protein isolation.
HostingRepository	PRIDE
AnnounceDate	2025-03-18
AnnouncementXML	Submission_2025-03-18_05:56:15.531.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD058165
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Cornelius Welke
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-22 02:36:48	ID requested
⏵ 1	2025-03-18 05:56:15	announced

10.6019/PXD058165;

submitter keyword: HFpEF,Mouse, Heart, HFD, NO2-OA

Anna Klinke
contact affiliation	Heart and Diabetes Center NRW, Bad Oeynhausen University Hospital of the Ruhr-Universität Bochum
contact email	aklinke@hdz-nrw.de
lab head
Cornelius Welke
contact affiliation	Agnes Wittenborg Institute for translational Cardiovascular Research Clinic for General and Interventional Cardiology/ Angiology
contact email	cwelke@hdz-nrw.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD058165

PRIDE project URI

• PRIDE
  1. PXD058165
     1. Label: PRIDE project
     2. Name: Nitro-oleic acid in a HFpEF two-hit mouse model of high fat diet and L-NAME