PXD058133
PXD058133 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Structural basis of RNA polymerase complexes in African swine fever virus |
Description | African swine fever virus is highly contagious and causes a fatal infectious disease in pigs, resulting in a significant global impact on pork supply. The African swine fever virus RNA polymerase serves as a crucial multifunctional protein complex responsible for genome transcription and regulation. Therefore, it is essential to investigate its structural and functional characteristics for the prevention and control of African swine fever. Here, we determine the structures of endogenous African swine fever virus RNA polymerase in both nucleic acid-free and elongation states. The African swine fever virus RNA polymerase shares similarities with the core of typical RNA polymerases, but possesses a distinct subunit M1249L. Notably, the dynamic binding mode of M1249L with RNA polymerase, along with the C-terminal tail insertion of M1249L in the active center of DNA-RNA scaffold binding, suggests the potential of M1249L to regulate RNA polymerase activity within cells. These results are important for understanding the transcription cycle of African swine fever virus and for developing antiviral strategies. |
HostingRepository | PRIDE |
AnnounceDate | 2025-02-14 |
AnnouncementXML | Submission_2025-02-14_06:56:45.671.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | 吴瑕 曾 |
SpeciesList | scientific name: African swine fever virus; NCBI TaxID: 10497; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-11-21 04:48:29 | ID requested | |
⏵ 1 | 2025-02-14 06:56:46 | announced |
Publication List
10.1038/s41467-024-55683-z; |
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H, Structural basis of RNA polymerase complexes in African swine fever virus. Nat Commun, 16(1):501(2025) [pubmed] |
Keyword List
submitter keyword: protein,African swine fever virus,LC-MSMS |
Contact List
Guoliang Zhu | |
---|---|
contact affiliation | Lanzhou University |
contact email | zhugl@lzu.edu.cn |
lab head | |
吴瑕 曾 | |
contact affiliation | 兰州大学 |
contact email | 2572557201@qq.com |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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