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PXD058133

PXD058133 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleStructural basis of RNA polymerase complexes in African swine fever virus
DescriptionAfrican swine fever virus is highly contagious and causes a fatal infectious disease in pigs, resulting in a significant global impact on pork supply. The African swine fever virus RNA polymerase serves as a crucial multifunctional protein complex responsible for genome transcription and regulation. Therefore, it is essential to investigate its structural and functional characteristics for the prevention and control of African swine fever. Here, we determine the structures of endogenous African swine fever virus RNA polymerase in both nucleic acid-free and elongation states. The African swine fever virus RNA polymerase shares similarities with the core of typical RNA polymerases, but possesses a distinct subunit M1249L. Notably, the dynamic binding mode of M1249L with RNA polymerase, along with the C-terminal tail insertion of M1249L in the active center of DNA-RNA scaffold binding, suggests the potential of M1249L to regulate RNA polymerase activity within cells. These results are important for understanding the transcription cycle of African swine fever virus and for developing antiviral strategies.
HostingRepositoryPRIDE
AnnounceDate2025-02-14
AnnouncementXMLSubmission_2025-02-14_06:56:45.671.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitter吴瑕 曾
SpeciesList scientific name: African swine fever virus; NCBI TaxID: 10497;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-21 04:48:29ID requested
12025-02-14 06:56:46announced
Publication List
10.1038/s41467-024-55683-z;
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H, Structural basis of RNA polymerase complexes in African swine fever virus. Nat Commun, 16(1):501(2025) [pubmed]
Keyword List
submitter keyword: protein,African swine fever virus,LC-MSMS
Contact List
Guoliang Zhu
contact affiliationLanzhou University
contact emailzhugl@lzu.edu.cn
lab head
吴瑕 曾
contact affiliation兰州大学
contact email2572557201@qq.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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