PXD058106

PXD058106 is an original dataset announced via ProteomeXchange.

Title	The Ratio of Immunogenicity: A Novel Metric to Rank the Relative Strength of an Individual Antigen’s Capacity to Stimulate an Antigen-Specific IgG Response.
Description	Across the fields of immunology and medicine, the ability to identify and develop therapeutic strategies against primary (i.e. inciting) and secondary (i.e. perpetuating) antigenic proteins has potential to transform basic science and clinical practice. Despite significant in silico and in vitro advancements in the ability to predict antigenic proteins, difficulties in validating individual antigen in vivo immunogenicity dramatically reduces the number of targetable candidates. Here, we describe a novel, quantitative metric, termed the Ratio of Immunogenicity (ROI), which can be utilized to stratify antigens based on their relative immunogenicity (i.e., capacity to stimulate an IgG response). By combining data on the magnitude of the immune response and abundance (i.e. dose) of individual antigens in an in vivo system, a continuum of ROI values can be calculated. This study validates the ROI as a powerful and versatile tool which could be used to guide development of “protective” or predict “pathologic” antigen-specific immune responses
HostingRepository	PRIDE
AnnounceDate	2026-05-25
AnnouncementXML	Submission_2026-05-24_16:34:51.104.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD058106
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Benjamin Madden
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: NEWT:9913;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-20 14:59:29	ID requested
⏵ 1	2026-05-24 16:34:51	announced

Shortreed NA, Griffiths LG, The Ratio of Immunogenicity: A quantitative metric to identify highly immunogenic protein antigens to improve tissue-engineered biomaterials. Biomaterials, 331():124134(2026) [pubmed]

10.1016/j.biomaterials.2026.124134;

10.6019/PXD058106;

submitter keyword: LC-MSMS,Antigen detection, immune response, bovine pericardium

Leigh Griffiths Ph.D. MRCVS
contact affiliation	Professor of Medicine Cardiology lab Research
contact email	Griffiths.Leigh@mayo.edu
lab head
Benjamin Madden
contact affiliation	Mayo Clinic
contact email	madden.benjamin@mayo.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD058106
     1. Label: PRIDE project
     2. Name: The Ratio of Immunogenicity: A Novel Metric to Rank the Relative Strength of an Individual Antigen’s Capacity to Stimulate an Antigen-Specific IgG Response.