PXD058081

PXD058081 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Comparison of SJSA-1 and MCF-7 whole proteome after Navtemadlin treatment
Description	Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. In this experiment, we compare the whole proteme of MCF-7 and SJSA-1 cells following Navtemadlin treatment in order to gain an insight into the cause of the observed differences in the off-target profile of this molecule in the two cell lines.
HostingRepository	PRIDE
AnnounceDate	2025-04-28
AnnouncementXML	Submission_2025-04-28_07:13:47.978.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Amrita Date
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF HT

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-20 01:33:56	ID requested
⏵ 1	2025-04-28 07:13:48	announced

Publication List

Date A, Wall A, Zhang P, Houghton JW, Lu J, Thomas AM, Kova, č, i, č T, Wilson AJ, Tate EW, Barnard A, Affinity-based protein profiling of MDM2 inhibitor Navtemadlin. Chem Sci, 16(16):6886-6894(2025) [pubmed]
10.1039/d5sc00120j;

Date A, Wall A, Zhang P, Houghton JW, Lu J, Thomas AM, Kova, č, i, č T, Wilson AJ, Tate EW, Barnard A, Affinity-based protein profiling of MDM2 inhibitor Navtemadlin. Chem Sci, 16(16):6886-6894(2025) [pubmed]

10.1039/d5sc00120j;

Keyword List

submitter keyword: whole proteome,Navtemadlin, SJSA-1, MCF-7

submitter keyword: whole proteome,Navtemadlin, SJSA-1, MCF-7

Contact List

Anna Barnard
contact affiliation	Imperial College London
contact email	a.barnard@imperial.ac.uk
lab head
Amrita Date
contact affiliation	Imperial College London
contact email	a.date19@imperial.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD058081
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD058081

PRIDE project URI

Repository Record List

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