PXD058079

PXD058079 is an original dataset announced via ProteomeXchange.

Title	MFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
Description	To elucidate which secreted factors in tumor tissues (TTs) are responsible for the upregulation of UBE4A as the tumor progresses, we inoculated tumors in mice and analyzed the 2- and 4-week TT fluid by mass spectrometry (MS). By combining molecular weight cut off(MWCO) and the identification of secreted proteins, we identified three candidate proteins.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_04:58:56.462.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD058079
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	peihan wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-20 00:05:15	ID requested
⏵ 1	2025-05-07 04:58:57	announced

10.6019/PXD058079;

10.1016/j.xcrm.2024.101922;

Wang W, Chen J, Wang S, Sun X, Yang J, Yu P, Hu G, Wang J, Zhang J, Qiao S, Wang J, Zhang G, He Y, Feng H, Cai Z, MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1. Cell Rep Med, 6(2):101922(2025) [pubmed]

submitter keyword: anti-PD-1-therapy resistance, UBE4A,Extracellular vesicles, MFGE8, PD-L1

Zhijian Cai
contact affiliation	Institute of Immunology and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
contact email	caizj@zju.edu.cn
lab head
peihan wu
contact affiliation	Westlake University
contact email	wupeihan@westlake.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058079

PRIDE project URI

• PRIDE
  1. PXD058079
     1. Label: PRIDE project
     2. Name: MFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1