PXD058077

PXD058077 is an original dataset announced via ProteomeXchange.

Title	N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease
Description	Anti-synthetase syndrome (ASS), a subtype of idiopathic inflammatory myopathy (IMM), is characterized by distinctive skin rashes, proximal muscle weakness, and interstitial lung disease (ILD). The etiology of ASS remains largely unknown, and patients endure a poor quality of life and are prone to pulmonary infection. Recent studies have highlighted the potential role of aberrant glycosylation of immunoglobulin G (IgG) in the development of autoimmune diseases. However, the specific N-glycosylation patterns of IgG in ASS have not yet been fully elucidated. In this study, we employed GlycoQuant, a method for intact glycopeptide analysis, to investigate the intact N-glycopeptides of IgG from 30 ASS patients and 30 healthy controls (HC). Our analysis revealed 13 differentially expressed intact N-glycopeptides in ASS. Furthermore, we observed a significant increase in fucose alongside a marked decrease in N-acetylneuraminic acid levels among ASS patients. Crucially, alterations in IgG N-glycosylation correlated with the disease severity. In conclusion, this study provides a thorough overview of IgG N-glycosylation patterns in ASS, laying a solid foundation for future research in this area.
HostingRepository	iProX
AnnounceDate	2024-11-20
AnnouncementXML	Submission_2025-08-20_19:10:47.318.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yong Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	deaminated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-19 23:22:17	ID requested
1	2024-11-19 23:22:34	announced
⏵ 2	2025-08-20 19:10:48	announced	2025-08-21: Add info.

Zhao J, Li Y, Ling Y, Wu T, Wu Y, Tan C, Cheng L, Huang D, Liu Y, Zhang Y, N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease. Front Immunol, 16():1538219(2025) [pubmed]

submitter keyword: Anti-synthetase syndrome (ASS), N-glycosylation, Glycopeptide, Immunoglobulin G (IgG)

Yong Zhang
contact affiliation	West China Hospital, Sichuan University
contact email	nankai1989@foxmail.com
lab head
Yong Zhang
contact affiliation	West China Hospital, Sichuan University
contact email	nankai1989@foxmail.com
dataset submitter

iProX dataset URI