⮝ Full datasets listing

PXD058053

PXD058053 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleWhole proteome time course experiment in SJSA-1 cells
DescriptionNavtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. In this experiment, we test the effect of Navtemadlin treatment on protein expression in SJSA-1 cells over the course of 24 h.
HostingRepositoryPRIDE
AnnounceDate2025-04-28
AnnouncementXMLSubmission_2025-04-28_07:23:57.297.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAmrita Date
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumenttimsTOF HT
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-19 12:16:30ID requested
12025-04-28 07:23:58announced
Publication List
Date A, Wall A, Zhang P, Houghton JW, Lu J, Thomas AM, Kova, č, i, č T, Wilson AJ, Tate EW, Barnard A, Affinity-based protein profiling of MDM2 inhibitor Navtemadlin. Chem Sci, 16(16):6886-6894(2025) [pubmed]
10.1039/d5sc00120j;
Keyword List
submitter keyword: whole proteome,time course, SJSA-1
Contact List
Anna Barnard
contact affiliationImperial College London
contact emaila.barnard@imperial.ac.uk
lab head
Amrita Date
contact affiliationImperial College London
contact emaila.date19@imperial.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD058053
PRIDE project URI
Repository Record List
[ + ]