PXD058049

PXD058049 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Revealing Melanoma Cell Proteome Transformations with Silver Nanoparticles: An Innovative Comparative Study
Description	Addressing the challenges of melanoma, including its aggressive nature and treatment resistance. This study explores the application of silver nanoparticles (AgNPs) synthesized via conventional and green methods. By examining proteomic changes in A375 melanoma cells, we identify key disruptions in cell viability and gene activity. The DIA MS/SWATH MS analysis generates a set of differentially expressed proteins with respect to AgNPs. This allows us to identify new potential regulatory mechanisms and molecular pathways. AgNP exposure leads to oxidative stress, mitochondrial dysfunction, and activation of apoptosis pathways, revealing the potential of AgNPs in melanoma treatment. This comprehensive analysis highlights the promise of eco-friendly nanoparticle synthesis in developing effective anti-cancer therapies.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_06:26:00.698.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jakub Faktor
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-19 07:41:29	ID requested
⏵ 1	2025-05-07 06:26:01	announced

Publication List

Martano S, Faktor J, Kote S, Cascione M, Di Corato R, Faktorova D, Semeraro P, Rizzello L, Leporatti S, Rinaldi R, De Matteis V, DIA/SWATH-Mass Spectrometry Revealing Melanoma Cell Proteome Transformations with Silver Nanoparticles: An Innovative Comparative Study. Int J Mol Sci, 26(5):(2025) [pubmed]
10.3390/ijms26052029;

Martano S, Faktor J, Kote S, Cascione M, Di Corato R, Faktorova D, Semeraro P, Rizzello L, Leporatti S, Rinaldi R, De Matteis V, DIA/SWATH-Mass Spectrometry Revealing Melanoma Cell Proteome Transformations with Silver Nanoparticles: An Innovative Comparative Study. Int J Mol Sci, 26(5):(2025) [pubmed]

10.3390/ijms26052029;

Keyword List

submitter keyword: Melanoma, Silver nanoparticles (AgNPs), DIA MS, Nanomedicine, SWATH MS, Proteomics,Green Nanoparticles, Anti-cancer

submitter keyword: Melanoma, Silver nanoparticles (AgNPs), DIA MS, Nanomedicine, SWATH MS, Proteomics,Green Nanoparticles, Anti-cancer

Contact List

Sachin Kote
contact affiliation	International Centre for Cancer Vaccine Science, University of Gdansk, Kladki 24, 80-822 Gdansk, Poland
contact email	sachin.kote@ug.edu.pl
lab head
Jakub Faktor
contact affiliation	University of Gdansk Kladki 24 Gdansk
contact email	jakub.faktor@ug.edu.pl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058049
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058049

PRIDE project URI

Repository Record List

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