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PXD058036

PXD058036 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAfBPP of Navtemadlin probes in MCF-7 cells
DescriptionNavtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. The selectivity of this molecule is poorly understood. So we synthesised and validated two photoactivatable clickable probes of Navtemadlin. This data shows the proteins enriched upon treatment of MCF-7 cells with these probes.
HostingRepositoryPRIDE
AnnounceDate2025-04-28
AnnouncementXMLSubmission_2025-04-28_07:14:37.330.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAmrita Date
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumenttimsTOF HT
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-19 04:26:29ID requested
12025-04-28 07:14:38announced
Publication List
Date A, Wall A, Zhang P, Houghton JW, Lu J, Thomas AM, Kova, č, i, č T, Wilson AJ, Tate EW, Barnard A, Affinity-based protein profiling of MDM2 inhibitor Navtemadlin. Chem Sci, 16(16):6886-6894(2025) [pubmed]
10.1039/d5sc00120j;
Keyword List
submitter keyword: Navtemadlin, MCF-7,AfBPP
Contact List
Anna Barnard
contact affiliationImperial College London
contact emaila.barnard@imperial.ac.uk
lab head
Amrita Date
contact affiliationImperial College London
contact emaila.date19@imperial.ac.uk
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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