PXD058033 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | AfBPP of Navtemadlin probes in SJSA-1 cells |
Description | Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. The selectivity of this molecule is poorly understood. So we synthesised and validated two photoactivatable clickable probes of Navtemadlin. This data shows the proteins enriched upon treatment of SJSA-1 cells with these probes. |
HostingRepository | PRIDE |
AnnounceDate | 2025-04-28 |
AnnouncementXML | Submission_2025-04-28_07:17:43.274.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Amrita Date |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | timsTOF HT |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-11-19 03:47:32 | ID requested | |
⏵ 1 | 2025-04-28 07:17:44 | announced | |
Publication List
Date A, Wall A, Zhang P, Houghton JW, Lu J, Thomas AM, Kova, č, i, č T, Wilson AJ, Tate EW, Barnard A, Affinity-based protein profiling of MDM2 inhibitor Navtemadlin. Chem Sci, 16(16):6886-6894(2025) [pubmed] |
10.1039/d5sc00120j; |
Keyword List
ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
submitter keyword: Navtemadlin, SJSA-1,AfBPP |
Contact List
Anna Barnard |
contact affiliation | Imperial College London |
contact email | a.barnard@imperial.ac.uk |
lab head | |
Amrita Date |
contact affiliation | Imperial College London |
contact email | a.date19@imperial.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD058033 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058033
- Label: PRIDE project
- Name: AfBPP of Navtemadlin probes in SJSA-1 cells