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PXD057972

PXD057972 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleExtracellular vesicles from immortalised human amniotic epithelial cells reduce hepatic fibrosis in mice with Steatohepatitis and Hepatocellular Carcinoma
Descriptionevaluated the preclinical efficacy of immortalised hAEC EVs in a murine model of MASH and HCC. This model captures the histological, metabolic and immunological dysregulation seen in human MASH within 12 weeks and progression to HCC by 24 weeks. In this study we evaluated the effect of ihAEC EVs on steatosis, fibrosis, inflammation and liver regeneration and further characterized both protein and miRNA cargo to better elucidate the potential mechanisms of ihAEC EVs action in the setting of experimental MASLD/MASH.
HostingRepositoryMassIVE
AnnounceDate2025-02-11
AnnouncementXMLSubmission_2025-02-11_13:44:04.801.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDavid Greening
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListAcetyl
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-17 20:08:45ID requested
12025-02-11 13:44:05announced
Publication List
no publication
Keyword List
submitter keyword: stem cells, Extracellular vesicles, fibrosis, DatasetType:Proteomics
Contact List
David Greening
contact affiliationBaker Heart & Diabetes Institute
contact emaildavid.greening@baker.edu.au
lab head
David Greening
contact affiliationBaker Heart & Diabetes Institute
contact emaildavid.greening@baker.edu.au
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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