PXD057972

PXD057972 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Extracellular vesicles from immortalised human amniotic epithelial cells reduce hepatic fibrosis in mice with Steatohepatitis and Hepatocellular Carcinoma
Description	evaluated the preclinical efficacy of immortalised hAEC EVs in a murine model of MASH and HCC. This model captures the histological, metabolic and immunological dysregulation seen in human MASH within 12 weeks and progression to HCC by 24 weeks. In this study we evaluated the effect of ihAEC EVs on steatosis, fibrosis, inflammation and liver regeneration and further characterized both protein and miRNA cargo to better elucidate the potential mechanisms of ihAEC EVs action in the setting of experimental MASLD/MASH.
HostingRepository	MassIVE
AnnounceDate	2025-02-11
AnnouncementXML	Submission_2025-02-11_13:44:04.801.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Greening
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Acetyl
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-17 20:08:45	ID requested
⏵ 1	2025-02-11 13:44:05	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: stem cells, Extracellular vesicles, fibrosis, DatasetType:Proteomics

submitter keyword: stem cells, Extracellular vesicles, fibrosis, DatasetType:Proteomics

Contact List

David Greening
contact affiliation	Baker Heart & Diabetes Institute
contact email	david.greening@baker.edu.au
lab head
David Greening
contact affiliation	Baker Heart & Diabetes Institute
contact email	david.greening@baker.edu.au
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000096440/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000096440/