PXD057972
PXD057972 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Extracellular vesicles from immortalised human amniotic epithelial cells reduce hepatic fibrosis in mice with Steatohepatitis and Hepatocellular Carcinoma |
Description | evaluated the preclinical efficacy of immortalised hAEC EVs in a murine model of MASH and HCC. This model captures the histological, metabolic and immunological dysregulation seen in human MASH within 12 weeks and progression to HCC by 24 weeks. In this study we evaluated the effect of ihAEC EVs on steatosis, fibrosis, inflammation and liver regeneration and further characterized both protein and miRNA cargo to better elucidate the potential mechanisms of ihAEC EVs action in the setting of experimental MASLD/MASH. |
HostingRepository | MassIVE |
AnnounceDate | 2025-02-11 |
AnnouncementXML | Submission_2025-02-11_13:44:04.801.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | David Greening |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | Acetyl |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-11-17 20:08:45 | ID requested | |
⏵ 1 | 2025-02-11 13:44:05 | announced |
Publication List
no publication |
Keyword List
submitter keyword: stem cells, Extracellular vesicles, fibrosis, DatasetType:Proteomics |
Contact List
David Greening | |
---|---|
contact affiliation | Baker Heart & Diabetes Institute |
contact email | david.greening@baker.edu.au |
lab head | |
David Greening | |
contact affiliation | Baker Heart & Diabetes Institute |
contact email | david.greening@baker.edu.au |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000096440/ |