PXD057946

PXD057946 is an original dataset announced via ProteomeXchange.

Title	Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport
Description	The MetaboHealth score is a highly informative health indicator in ageing studies and yet contains only a small number of metabolites. Here we estimate the heritability of the score in 726 monozygotic (MZ) and 450 dizygotic (DZ) twin pairs, and test for association with plasma proteins by comparing extreme scoring individuals selected from two large population cohorts -the Leiden Longevity Study (LLS) and the Rotterdam Study (RS) and discordant monozygotic twin pairs from the Netherlands Twin Register (NTR). The heritability for the MetaboHealth score was estimated at 40%. In 50 high and 50 low scoring MetaboHealth groups from LLS and RS, we uncovered significant differences in plasma proteins, notably in 3 (out of 15) cytokines (GDF15, IL6, and MIG), and 106 proteins (out of 289) as determined by Mass Spectrometry based proteomics analysis. A high MetaboHealth score associated with an increased level for 42 serum proteins, predominantly linked to inflammation and immune response, including CRP and HPT. A low score associated with decreased levels of 71 proteins enriched in high-density lipoprotein (HDL) remodeling and cholesterol transport pathways, featuring proteins such as APOA1, APOA2, APOA4, and TETN. In MZ twins selected for maximal discordance within a pair we found 68 serum proteins associated with the MetaboHealth score indicating that a minor part of the associations observed in LLS and RS is likely explained by genetic influences. Taken together, our study sheds light on the intricate interplay between MetaboHealth, plasma proteins, cytokines, and genetic influences, paving the way for future investigations aimed at optimizing this mortality risk indicator.
HostingRepository	PRIDE
AnnounceDate	2025-09-15
AnnouncementXML	Submission_2025-09-14_19:34:00.428.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nicolas Drouin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-15 10:25:52	ID requested
⏵ 1	2025-09-14 19:34:05	announced

10.1186/s12979-025-00527-7;

Bizzarri D, van den Akker EB, Reinders MJT, Pool R, Beekman M, Lakenberg N, Drouin N, Stecker KE, Heck AJR, Knol EF, Vergeer JM, Ikram MA, Ghanbari M, van Gool AJ, Deelen J, Bbmri-Nl, Boomsma DI, Slagboom PE, Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport. Immun Ageing, 22(1):34(2025) [pubmed]

submitter keyword: Plasma proteomics, metabolomics,Aging, MetaboHealth scores, masss spectrometry, Cytokines, Immunoassay

Albert Johannes
contact affiliation	Biomolecular Mass Spectrometry and Proteomics, University of Utrecht, the Netherlands
contact email	A.J.R.Heck@uu.nl
lab head
Nicolas Drouin
contact affiliation	University of Utrecht
contact email	n.f.p.drouin@uu.nl
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD057946
     1. Label: PRIDE project
     2. Name: Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport