PXD057928

PXD057928 is an original dataset announced via ProteomeXchange.

Title	Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Description	Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various research models, including PDAC cells, spheroids, organoids, and tissues derived from murine and human samples. Identical mass spectrometry-based proteomics was applied across the different models. Preparation and validation of the research models and the proteomics were described in detail. The assembly datasets we present here may contribute to the data collection on PDAC, which will be useful for systems modeling, data mining, knowledge discovery in databases, and bioinformatics of individual models. Further data analysis may lead to generation of research hypotheses, predictions of targets for diagnosis and treatment and relationships between data variables. bridging the gap between preclinical research and clinical trials, thus enhancing the possibilities for discovering early diagnostic biomarkers and effective therapeutic targets.
HostingRepository	PRIDE
AnnounceDate	2024-12-18
AnnouncementXML	Submission_2024-12-18_11:46:14.914.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Animesh Sharma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	deamidated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-15 04:36:25	ID requested
⏵ 1	2024-12-18 11:46:15	announced

Dataset with its publication pending

submitter keyword: Human PDAC organoids

Lars Hagen
contact affiliation	Daglig leder, PROMEC Institutt for klinisk og molekylær medisin lars.hagen@ntnu.no 73598508 72573342 Laboratoriesenteret, 231.04.008, Øya, Erling Skjalgssons gate 1
contact email	lars.hagen@ntnu.no
lab head
Animesh Sharma
contact affiliation	Engineer at NTNU, Norway
contact email	sharma.animesh@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD057928

PRIDE project URI

• PRIDE
  1. PXD057928
     1. Label: PRIDE project
     2. Name: Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma