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PXD057893

PXD057893 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDistinguishing N-Terminal Methylation from Near-isobaric Modifications by Statistical Analysis of Mass Error Distributions of Fragment Ions
Descriptionalpha-N-terminal methylation is an understudied post-translational modification with presumed functions involving protein-protein and/or protein-DNA interaction. The covalent addition of mono-, di-, trimethyl groups to free alpha-amino group has proven to be difficult to profile globally by mass spectrometry due to trace endogenous amount and interference from near-isobaric modifications such as Nt-acetylation, even after N-terminome enrichment. To address this problem, we assume that in each MS2 spectrum b-ions will have a different mass error distribution compared to y-ions if the spectrum is falsely assigned to near-isobaric Nt-modification and exploit this statistically to correct the Nt-modification, a procedure we name as mass error test (MET)
HostingRepositoryMassIVE
AnnounceDate2025-05-22
AnnouncementXMLSubmission_2025-05-22_21:22:01.988.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterHankyul Lee
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListAcetyl; Trimethyl; Formyl; Dimethyl; Methyl; Acetyl:2H(3); Oxidation; Carbamidomethyl
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-14 05:38:05ID requested
12025-05-22 21:22:02announced
Publication List
no publication
Keyword List
submitter keyword: N-terminal methylation, mass error test, post-translational modification, mass error distribution, near isobaric modification, DatasetType:Proteomics
Contact List
Cheolju lee
contact affiliationKorea Institute of Science and Technology
contact emailclee270@kist.re.kr
lab head
Hankyul Lee
contact affiliationKIST
contact emaildlgksruf321@kist.re.kr
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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