PXD057882
PXD057882 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comprehensive N-Glycomics Profiling of Urinary Extracellular Vesicles Identifies a Novel Biomarker Panel for Diagnosis of Bladder Cancer |
Description | Bladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges.Urinary extracellular vesicles (EVs) is a particularly promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine and bladder. We investigate biomarkers for bladder cancer diagnosis based on an N-glycomics study involving the clinical cohort of 333 individuals. Finally, eight N-glycans were screened out to construct a diagnostic model, able to well differentiate bladder cancer from healthy individuals.To further understand the functions and potential roles of urinary EVs, we conducted N-glycoproteomic analysis of urinary EVs from the BC, UB, UM, and HC groups to explore the nature of glycoproteins carrying cancer-associated N-glycan signatures in EVs. |
HostingRepository | iProX |
AnnounceDate | 2024-11-14 |
AnnouncementXML | Submission_2025-02-26_17:58:07.480.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yang Li |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-11-13 23:28:44 | ID requested | |
⏵ 1 | 2025-02-26 17:58:07 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: urinary extracellular vesicles;bladder cancer;N-glycosylation;biomarker |
Contact List
Haojie Lu | |
---|---|
contact affiliation | Fudan University |
contact email | luhaojie@fudan.edu.cn |
lab head | |
Yang Li | |
contact affiliation | Fudan University |
contact email | 251298630@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |