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PXD057882

PXD057882 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComprehensive N-Glycomics Profiling of Urinary Extracellular Vesicles Identifies a Novel Biomarker Panel for Diagnosis of Bladder Cancer
DescriptionBladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges.Urinary extracellular vesicles (EVs) is a particularly promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine and bladder. We investigate biomarkers for bladder cancer diagnosis based on an N-glycomics study involving the clinical cohort of 333 individuals. Finally, eight N-glycans were screened out to construct a diagnostic model, able to well differentiate bladder cancer from healthy individuals.To further understand the functions and potential roles of urinary EVs, we conducted N-glycoproteomic analysis of urinary EVs from the BC, UB, UM, and HC groups to explore the nature of glycoproteins carrying cancer-associated N-glycan signatures in EVs.
HostingRepositoryiProX
AnnounceDate2024-11-14
AnnouncementXMLSubmission_2025-02-26_17:58:07.480.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYang Li
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-13 23:28:44ID requested
12025-02-26 17:58:07announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: urinary extracellular vesicles;bladder cancer;N-glycosylation;biomarker
Contact List
Haojie Lu
contact affiliationFudan University
contact emailluhaojie@fudan.edu.cn
lab head
Yang Li
contact affiliationFudan University
contact email251298630@qq.com
dataset submitter
Full Dataset Link List
iProX dataset URI