⮝ Full datasets listing
PXD057854
PXD057854 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proximity interactomes of human PRICKLE1, PRICKLE2 and PRICKLE3 |
| Description | Prickle represents an evolutionarily conserved family of proteins that is specifically linked to Wnt/planar cell polarity (PCP) signalling. This signalling pathway is crucial for the correct polarization of epithelial cells along the plane of the epithelial tissue in both Drosophila and vertebrates. While three core components of this pathway—Frizzled, Dishevelled, and Vangl—have been extensively studied, the fourth component, Prickle, has received relatively little attention. Prickle proteins play a crucial role in vertebrate development, including processes such as early embryogenesis, neurulation, body axis elongation, and organogenesis. Furthermore, Prickle proteins have been implicated in cancer biology, where they participate in the regulation of cancer cell migration, a critical step in cancer metastasis. Additionally, Prickle family has been associated with various neurological, neurodegenerative, and autoimmune diseases. The role of Prickle is complex and multifaceted; however, it remains poorly understood. Consequently, the functions of individual PRICKLE isoforms in these processes require further investigation. In this study, we present a comprehensive and validated resource of the PRICKLE1-3 interactomes that can be explored by other research groups. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-09 |
| AnnouncementXML | Submission_2026-02-08_18:40:28.390.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | David Potesil |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-11-13 09:25:16 | ID requested | |
| ⏵ 1 | 2026-02-08 18:40:29 | announced |
Publication List
| Radaszkiewicz KA, Radaszkiewicz TW, Kol, á, ř, ov, á P, Pacl, í, kov, á P, G, ö, m, ö, ryov, á K, Novotn, á Š, Maia LA, Č, í, halov, á T, Le Y, B, á, rta T, Han, á, kov, á K, H, ý, skov, á A, Tripsianes K, Zdr, á, hal Z, Winkler C, Harno, š J, PRICKLE3 protects VANGL proteins from CK1-mediated phosphorylation and RNF43-mediated degradation. Commun Biol, 9(1):142(2025) [pubmed] |
| 10.1038/s42003-025-09422-9; |
Keyword List
| submitter keyword: HEK293 T-Rex, WNT/planar cell polarity (PCP) signalling,PRICKLE, miniTurboID |
Contact List
| Zbynek Zdrahal | |
|---|---|
| contact affiliation | Proteomics Core Facility and Research Group Proteomics, CEITEC-MU, Masaryk University, Brno, Czech Republic |
| contact email | zdrahal@sci.muni.cz |
| lab head | |
| David Potesil | |
| contact affiliation | Proteomics Core Facility and Research Group Proteomics CEITEC-MU Masaryk University Brno, Czech Republic |
| contact email | david.potesil@ceitec.muni.cz |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD057854 |
| PRIDE project URI |
Repository Record List
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