PXD057814
PXD057814 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma proteomics for novel biomarker discovery in childhood tuberculosis |
| Description | Failure to rapidly diagnose tuberculosis disease (TB) and initiate treatment is a driving factor of TB as a leading cause of death in children. Current TB diagnostic assays have poor performance in children, and identifying novel non-sputum-based TB biomarkers to improve pediatric TB diagnosis is a global priority. We sought to develop a plasma biosignature for TB by probing the plasma proteome of 511 children stratified by TB diagnostic classification and HIV status from sites in four low- and middle-income countries, using high-throughput data-independent acquisition mass-spectrometry (DIA-PASEF-MS). We identified 47 proteins differentially regulated between children with microbiologically confirmed TB from children with non-TB lower respiratory tract infection (Unlikely TB). We further employed machine learning to derive three parsimonious biosignatures encompassing 4, 5, or 6 proteins that achieved AUCs of 0.86-0.88 all of which exceeded the minimum WHO target product profile accuracy thresholds (70% specificity at 90% sensitivity, PPV 0.65-0.74, NPV 0.92-0.95) for a TB screening test. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-06-05 |
| AnnouncementXML | Submission_2025-06-05_17:47:43.950.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Justin M McKetney |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Acetyl; Pyro-carbamidomethyl; Glu->pyro-Glu; Gln->pyro-Glu; Carbamidomethyl; Oxidation |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-11-12 17:22:56 | ID requested | |
| ⏵ 1 | 2025-06-05 17:47:44 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Plasma, Mycobacterium tuberculosis, Proteomics, HIV, Biomarkers, DatasetType:Proteomics |
Contact List
| Danielle Swaney | |
|---|---|
| contact affiliation | UCSF |
| contact email | danielle.swaney@gladstone.ucsf.edu |
| lab head | |
| Justin M McKetney | |
| contact affiliation | UCSF |
| contact email | justinmcketney@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096394/ |
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