PXD057803 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting FOXA1 and FOXA2 Disrupts the Lineage-Specific Oncogenic Output in Prostate Cancer |
| Description | Activation of the androgen receptor (AR) is the key lineage-specific oncogenic pathway and the primary therapeutic target in prostate cancer. While AR signaling is enabled by the pioneer transcription factor FOXA1, its homolog FOXA2 is specifically expressed in advanced lineage plasticity prostate cancers that have lost the AR signaling axis. However, their roles and utility as drug targets remain incompletely characterized. Here, we show an unexpected collaboration of FOXA1 and FOXA2 in mediating AR-independent cell proliferation in different lineage plasticity cancer subtypes. Conversely, joint loss-of-function or pharmacologic disruption of FOXA1 and FOXA2 leads to the collapse of lineage-specific oncogenic transcription factors followed by cell cycle arrest. In summary, our findings uncover a druggable dependency for AR-positive and -negative prostate cancers. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-28 |
| AnnouncementXML | Submission_2026-01-27_18:01:34.615.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Matteo Pecoraro |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF; timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-12 08:52:02 | ID requested | |
| ⏵ 1 | 2026-01-27 18:01:35 | announced | |
Publication List
| 10.1016/j.celrep.2025.116324; |
| Formaggio N, Sgrignani J, Thillaiyampalam G, Lorenzi C, Cassanmagnago GA, Coazzoli M, Costanzo F, Uebelhart Y, Bossi D, Cassiano DC, Rinaldi A, Pecoraro M, Geiger R, Santoro R, Bolis M, Cavalli A, Theurillat JP, Targeting FOXA1 and FOXA2 disrupts the lineage-specific oncogenic output program in prostate cancer. Cell Rep, 44(10):116324(2025) [pubmed] |
Keyword List
| submitter keyword: FOXA1,AR negative Prostate Cancer, FOXA2, Targeting transcription factor, Chromatin |
Contact List
| Jean-Philippe Theurillat |
|---|
| contact affiliation | Institute of Oncology Research, Bellinzona, Switzerland |
| contact email | jean-philippe.theurillat@ior.usi.ch |
| lab head | |
| Matteo Pecoraro |
|---|
| contact affiliation | Institute for Research in Biomedicine, Via Francesco Chiesa 5 - CH-6500 Bellinzona |
| contact email | matteo.pecoraro@irb.usi.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057803
- Label: PRIDE project
- Name: Targeting FOXA1 and FOXA2 Disrupts the Lineage-Specific Oncogenic Output in Prostate Cancer
