PXD057794

PXD057794 is an original dataset announced via ProteomeXchange.

Title	RAS-p110α signalling pathway in macrophages and its impact on both the initiation and resolution of inflammation
Description	This study presents a secretome analysis of bone marrow-derived macrophages (BMDMs) from wild-type (WT) and RAS-p110α-disrupted macrophages. Samples were collected under both unstimulated conditions and during phagocytosis of apoptotic cells. The aim was to identify differential regulatory factors secreted by macrophages across these four conditions, highlighting the impact of disrupted RAS-p110α signaling on macrophage function and secretome composition.
HostingRepository	PRIDE
AnnounceDate	2025-04-28
AnnouncementXML	Submission_2025-04-28_05:54:39.467.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD057794
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Vinothini Rajeeve
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-12 06:35:27	ID requested
⏵ 1	2025-04-28 05:54:40	announced

10.7554/elife.94590;

10.6019/PXD057794;

Rosell A, Krygowska AA, Alc, ó, n P, é, rez M, Cuesta C, Voisin MB, de Paz J, Sanz-Fraile H, Rajeeve V, Carreras-Gonz, á, lez A, Berral-Gonz, á, lez A, Swinyard O, Gaband, é, -Rodr, í, guez E, Downward J, Alcaraz J, Anguita J, Garc, í, a-Mac, í, as C, De Las Rivas J, Cutillas PR, Castellano Sanchez E, signalling in macrophages is required for effective inflammatory response and resolution of inflammation. Elife, 13():(2025) [pubmed]

submitter keyword: proteomics, inflammation, macrophages,RAS-PI3K, LC-MS/MS

Professor Pedro R. Cutillas
contact affiliation	Mass Spectrometry Facility Barts Cancer Institute Lab 1.01 1st floor Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ
contact email	p.cutillas@qmul.ac.uk
lab head
Vinothini Rajeeve
contact affiliation	Centre for Haemato Oncology
contact email	v.rajeeve@qmul.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD057794

PRIDE project URI

• PRIDE
  1. PXD057794
     1. Label: PRIDE project
     2. Name: RAS-p110α signalling pathway in macrophages and its impact on both the initiation and resolution of inflammation