PXD057783 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system |
Description | Mallick et al. showed that the hematopoietic stem cells exhibited exclusive tropism towards colorectal cancer stem cells (CRC-CSC). HSCs-derived conditioned media disrupted the 26s proteasome, HSP90, inducing mitochondrial alteration and apoptosis in CRC CSCs. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-08 |
AnnouncementXML | Submission_2025-05-07_22:52:09.016.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Keshava Prasad T. S. |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-11-12 03:03:20 | ID requested | |
⏵ 1 | 2025-05-07 22:52:09 | announced | |
Publication List
10.1016/j.biocel.2025.106773; |
Mallick S, Narayana VK, Rai AB, Upadhyay SS, Prasad TSK, P SS, Bose B, Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system. Int J Biochem Cell Biol, 184():106773(2025) [pubmed] |
Keyword List
submitter keyword: autophagy, proteomics, cancer stem cells, HSP,Hematopoietic stem cells, Tropism, conditioned media, 26S proteasome, colorectal cancer |
Contact List
TSK Prasad |
contact affiliation | Professor and Deputy Director, Center for Systems Biology and Molecular Medicine,Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore |
contact email | tskprasad@gmail.com |
lab head | |
Keshava Prasad T. S. |
contact affiliation | Professor and Deputy Director, Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Mangalore, India |
contact email | keshav@ibioinformatics.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD057783 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057783
- Label: PRIDE project
- Name: Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system