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PXD057783

PXD057783 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system
DescriptionMallick et al. showed that the hematopoietic stem cells exhibited exclusive tropism towards colorectal cancer stem cells (CRC-CSC). HSCs-derived conditioned media disrupted the 26s proteasome, HSP90, inducing mitochondrial alteration and apoptosis in CRC CSCs.
HostingRepositoryPRIDE
AnnounceDate2025-05-08
AnnouncementXMLSubmission_2025-05-07_22:52:09.016.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKeshava Prasad T. S.
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-12 03:03:20ID requested
12025-05-07 22:52:09announced
Publication List
10.1016/j.biocel.2025.106773;
Mallick S, Narayana VK, Rai AB, Upadhyay SS, Prasad TSK, P SS, Bose B, Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system. Int J Biochem Cell Biol, 184():106773(2025) [pubmed]
Keyword List
submitter keyword: autophagy, proteomics, cancer stem cells, HSP,Hematopoietic stem cells, Tropism, conditioned media, 26S proteasome, colorectal cancer
Contact List
TSK Prasad
contact affiliationProfessor and Deputy Director, Center for Systems Biology and Molecular Medicine,Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore
contact emailtskprasad@gmail.com
lab head
Keshava Prasad T. S.
contact affiliationProfessor and Deputy Director, Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Mangalore, India
contact emailkeshav@ibioinformatics.org
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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