PXD057783

PXD057783 is an original dataset announced via ProteomeXchange.

Title	Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system
Description	Mallick et al. showed that the hematopoietic stem cells exhibited exclusive tropism towards colorectal cancer stem cells (CRC-CSC). HSCs-derived conditioned media disrupted the 26s proteasome, HSP90, inducing mitochondrial alteration and apoptosis in CRC CSCs.
HostingRepository	PRIDE
AnnounceDate	2025-05-08
AnnouncementXML	Submission_2025-05-07_22:52:09.016.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Keshava Prasad T. S.
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-12 03:03:20	ID requested
⏵ 1	2025-05-07 22:52:09	announced

10.1016/j.biocel.2025.106773;

Mallick S, Narayana VK, Rai AB, Upadhyay SS, Prasad TSK, P SS, Bose B, Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system. Int J Biochem Cell Biol, 184():106773(2025) [pubmed]

submitter keyword: autophagy, proteomics, cancer stem cells, HSP,Hematopoietic stem cells, Tropism, conditioned media, 26S proteasome, colorectal cancer

TSK Prasad
contact affiliation	Professor and Deputy Director, Center for Systems Biology and Molecular Medicine,Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore
contact email	tskprasad@gmail.com
lab head
Keshava Prasad T. S.
contact affiliation	Professor and Deputy Director, Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Mangalore, India
contact email	keshav@ibioinformatics.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD057783

PRIDE project URI

• PRIDE
  1. PXD057783
     1. Label: PRIDE project
     2. Name: Hematopoietic stem cell conditioned media induces apoptosis in colorectal cancer stem cells via dysregulation of HSP90 and 26S proteasome system