PXD057767
PXD057767 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nascent proteomics profiling reveals NNMT as a regulator to promote drug resistance in lung cancer |
| Description | In this work, we adopted a workflow including metabolic labeling, TAD-resin enrichment and MS quantification for a comprehensive understanding the changes of nascent proteins at the initial stage of drug treatment. Our investigation of nascent proteome alterations provided new insights into immediate responses of cancer cells to AZD9291 treatment, highlighting NNMT as a potential therapeutic target. |
| HostingRepository | iProX |
| AnnounceDate | 2024-11-11 |
| AnnouncementXML | Submission_2024-11-11_18:59:40.357.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhanwu Hou |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-11-11 18:59:19 | ID requested | |
| ⏵ 1 | 2024-11-11 18:59:40 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: nascent proteome, cancer drug resistance, NNMT, EGFR inhibitor, phosphorylation |
Contact List
| Huadong Liu | |
|---|---|
| contact affiliation | University of Health and Rehabilitation Sciences |
| contact email | huadongliu@xjtu.edu.cn |
| lab head | |
| Zhanwu Hou | |
| contact affiliation | Xi'an Jiaotong University |
| contact email | xa_daniel@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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