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PXD057741

PXD057741 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNuclear VCP-like 2 (NVL2)-associated complex
DescriptionLC-MSMS analysis of NVL2-associated pre-60S complex. To obtain more insights into the molecular mechanism of this effects caused by the mutant NVL2 in pre-60S complexes,we searched for additional proteins that preferentially interact with the NVL2(E365Q/E682Q) in comparison with wild-type NVL2. Co-mmunoprecipitation was performed by using FLAG-tagged NVL2 (wild-type or E365Q/E682Q) as baits and their interacting proteins were analyzed by LC-MS/MS.
HostingRepositoryjPOST
AnnounceDate2025-01-31
AnnouncementXMLSubmission_2025-01-30_07:00:11.462.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKeiichi Izumikawa
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListS-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; 2-pyrrolidone-5-carboxylic acid (Gln); L-methionine sulfoxide
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-11 04:33:20ID requested
12025-01-30 07:00:12announced
Publication List
Hirooka Y, Izumikawa K, Miyao S, Ohga T, Nobe Y, Taoka M, Nagahama M, Pre-ribosomal WDR74 module coordinates the early and late pre-rRNA processing stages for the NVL2-mediated regulation of 60S ribosome biogenesis. Biochem Biophys Res Commun, 744():151175(2025) [pubmed]
Keyword List
submitter keyword: NVL2
Contact List
Masami Nagahama
lab head
Keiichi Izumikawa
contact affiliationMeiji pharmaceutical university
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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