PXD057741

PXD057741 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Nuclear VCP-like 2 (NVL2)-associated complex
Description	LC-MSMS analysis of NVL2-associated pre-60S complex. To obtain more insights into the molecular mechanism of this effects caused by the mutant NVL2 in pre-60S complexes,we searched for additional proteins that preferentially interact with the NVL2(E365Q/E682Q) in comparison with wild-type NVL2. Co-mmunoprecipitation was performed by using FLAG-tagged NVL2 (wild-type or E365Q/E682Q) as baits and their interacting proteins were analyzed by LC-MS/MS.
HostingRepository	jPOST
AnnounceDate	2025-01-31
AnnouncementXML	Submission_2025-01-30_07:00:11.462.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Keiichi Izumikawa
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; 2-pyrrolidone-5-carboxylic acid (Gln); L-methionine sulfoxide
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-11 04:33:20	ID requested
⏵ 1	2025-01-30 07:00:12	announced

Publication List

Hirooka Y, Izumikawa K, Miyao S, Ohga T, Nobe Y, Taoka M, Nagahama M, Pre-ribosomal WDR74 module coordinates the early and late pre-rRNA processing stages for the NVL2-mediated regulation of 60S ribosome biogenesis. Biochem Biophys Res Commun, 744():151175(2025) [pubmed]

Hirooka Y, Izumikawa K, Miyao S, Ohga T, Nobe Y, Taoka M, Nagahama M, Pre-ribosomal WDR74 module coordinates the early and late pre-rRNA processing stages for the NVL2-mediated regulation of 60S ribosome biogenesis. Biochem Biophys Res Commun, 744():151175(2025) [pubmed]

Keyword List

submitter keyword: NVL2

submitter keyword: NVL2

Contact List

Masami Nagahama
lab head
Keiichi Izumikawa
contact affiliation	Meiji pharmaceutical university
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003462/