⮝ Full datasets listing
PXD057738
PXD057738 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Pathogenesis of Diffuse Large B cell Lymphoma Proteogenotypes |
| Description | The clinical and molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) is incompletely understood. By integrating proteomic, transcriptomic and genomic data from 478 DLBCL tumors, we identify seven DLBCL proteogenotypes (PGs) reflecting specific pathophysiological features that span known molecular subtypes. PG4 is associated with poor outcome independent of established risk factors like cell-of-origin, international prognostic index, or genetic features. PG4 contains activated B cell-like and germinal center B cell-like tumors and genetically unclassified cases. It shares a dark-zone related B cell phenotype and shows enrichment for BTG1 mutations that can activate MYC. Single-cell sequencing and spatial transcriptomics reveal enhanced MYC and TCF3/4 transcriptional activity irrespective of MYC translocations. The PG4 tumor microenvironment is characterized by exhausted CD8+ T cells. Our study identifies common oncogenic themes underlying high-risk DLBCL tumors and provides a proteogenomic framework for future diagnostic and therapeutic approaches. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-04-30 |
| AnnouncementXML | Submission_2026-04-30_13:01:44.728.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Bj�rn H�upl |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl; Oxidation; Acetyl |
| Instrument | Q Exactive HF; Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-11-11 02:32:29 | ID requested | |
| ⏵ 1 | 2026-04-30 13:01:45 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: DLBCL, proteogenomics, latent variable modeling, DatasetType:Proteomics |
Contact List
| Thomas Oellerich | |
|---|---|
| contact affiliation | University Hospital, Goethe University Frankfurt |
| contact email | oellerich@em.uni-frankfurt.de |
| lab head | |
| Bj�rn H�upl | |
| contact affiliation | DKFZ/DKTK |
| contact email | b.haeupl@dkfz-heidelberg.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096371/ |
