PXD057721

PXD057721 is an original dataset announced via ProteomeXchange.

Title	Fam170a deficiency causes male infertility by impairing histone-to-protamine exchange during mouse spermiogenesis
Description	Families with sequence similarity 170 members A (Fam170a) deficiency caused abnormal sperm nuclear morphology and male infertility in mice, mirroring the observation of very low Fam170a transcription in sperm of infertile men with teratozoospermia.Fam170a directly interacted with the deubiquitinating enzyme Usp7 and promoted nuclear translocation of Usp7 in elongating sperm by its nuclear localization sequence, enhancing the deubiquitinating activity of Usp7 on testis-specific histone H2A and H2B variants. Collectively, our findings identified Fam170a as a previously unknown key regulator for sperm chromatin remodeling and revealed that histone deubiquitinating modification might also exert an essential role in the histone-to-protamine exchange.
HostingRepository	iProX
AnnounceDate	2024-11-10
AnnouncementXML	Submission_2024-11-10_22:35:54.747.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jinmei Cheng
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-10 22:35:10	ID requested
⏵ 1	2024-11-10 22:35:55	announced

Dataset with its publication pending

submitter keyword: IP-MS

Fei Sun
contact affiliation	Nantong University
contact email	sunfei@ntu.edu.cn
lab head
Jinmei Cheng
contact affiliation	Nantong University
contact email	chengjinmei@ntu.edu.cn
dataset submitter

iProX dataset URI