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PXD057713

PXD057713 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleOral delivery of a cholera toxin-binding protein protects against diarrhoea in experimental cholera
DescriptionOral cholera vaccines (OCVs) have become important components of strategies for cholera control, but the demand for OCVs has outstripped the supply2–4. There is a need for new cholera control measures for the one billion people living in cholera endemic regions5. The use of orally delivered single-domain antibodies has been proposed as a potential approach for the control of gastrointestinal pathogens6. Here, we describe the development of an orally deliverable bivalent VHH construct (BL3.2) that binds to the B-subunit of cholera toxin (CTXB). The epitope of CTXB for binding molecule BL3.2 was mapped by Hydrogen Deuterium Exchange HDX
HostingRepositoryPRIDE
AnnounceDate2025-02-24
AnnouncementXMLSubmission_2025-02-24_05:37:42.871.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDario Segura-Pena
SpeciesList scientific name: Vibrio cholerae H1; NCBI TaxID: 1093790;
ModificationListNo PTMs are included in the dataset
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-10 15:32:40ID requested
12025-02-24 05:37:43announced
Publication List
Dataset with its publication pending
Keyword List
ProteomeXchange project tag: Antibodies (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
submitter keyword: CTXB,HDX
Contact List
Nikolina Sekulic
contact affiliationInstitute for Basic Medical Sciences Department of Molecular Medicine Faculty of Medicine, University of Oslo
contact emailnikolina.sekulic@biotek.uio.no
lab head
Dario Segura-Pena
contact affiliationResearcher
contact emaildario.segura-pena@ncmm.uio.no
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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