PXD057712

PXD057712 is an original dataset announced via ProteomeXchange.

Title	Tenotomized Achilles tendons of MRL/MpJ mice show scar-mediated healing, but have superior recovery of biomechanical properties
Description	The purpose of this project is to determine changes in proteins and signaling pathways in injured tendons of C57BL/6j and MRL/MpJ mice. The MRL.MpJ mice have been reported to have a strong repair ability compared to that of C57BL/6j mice. Identifying signaling pathways in MRL/MpJ tendons that are distinct from C57BL/6j tendons will help us understand the molecular mechanisms underlying the better healing ability of MRL/MpJ mice. The samples include normal and injured Achilles tendons 4 weeks after tenotomy surgery obtained from male and female C57BL/6j and MRL/MpJ. The Achilles injury surgery was performed at 12 weeks of age. Normal tendons were obtained age, sex and strain-matched mice without surgery. The collected normal and inured tendons were subjected to proteomics.
HostingRepository	PRIDE
AnnounceDate	2025-05-16
AnnouncementXML	Submission_2025-05-16_07:44:56.023.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mehari Weldemariam
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-10 14:53:37	ID requested
⏵ 1	2025-05-16 07:44:56	announced

10.1101/2025.05.13.653102;

submitter keyword: Tendon C57BL/6j, injury, MRL/MpJ, Achilles tendon

Maureen A.
contact affiliation	University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD 21201
contact email	mkane@rx.umaryland.edu
lab head
Mehari Weldemariam
contact affiliation	University of Maryland Baltimore
contact email	mweldemariam@rx.umaryland.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD057712

PRIDE project URI

• PRIDE
  1. PXD057712
     1. Label: PRIDE project
     2. Name: Tenotomized Achilles tendons of MRL/MpJ mice show scar-mediated healing, but have superior recovery of biomechanical properties