PXD057698

PXD057698 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	tRF-22 RNA pulldown and Co-IP followed by LC-MS/MS in human cell samples
Description	tRNA-derived fragments (tRFs) play a crucial role in tumor progression. However, whether and how tRFs regulate the immune response in esophageal squamous cell carcinoma (ESCC) and their potential clinical applications remain unclear. tRF-22 enhances myeloid-derived suppressor cells (MDSCs) infiltration via a tRF-22–hnRNPAB–TGFβ2 axis, which in turn leads to the suppression of CD8+ T cells. Targeting tRF-22 or TGFβ2 reactivates antitumor immunity and synergistically enhances the effectiveness of anti-PD1 therapy in ESCC. Patients with lower tRF-22 levels exhibit better responses to immunotherapy and longer progression-free survival in our ESCC-ICB cohort.
HostingRepository	PRIDE
AnnounceDate	2026-01-12
AnnouncementXML	Submission_2026-01-11_16:09:08.530.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xin Qin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-09 05:25:40	ID requested
⏵ 1	2026-01-11 16:09:09	announced

Publication List

10.1002/advs.202505806;
Pan L, Qin X, Gong L, Liu H, Cheng B, Wang J, Hu Y, Zeng L, Wang Y, Song Q, Cheng Y, tRNA-Derived Fragment tRF-22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma. Adv Sci (Weinh), 13(1):e05806(2026) [pubmed]

10.1002/advs.202505806;

Pan L, Qin X, Gong L, Liu H, Cheng B, Wang J, Hu Y, Zeng L, Wang Y, Song Q, Cheng Y, tRNA-Derived Fragment tRF-22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma. Adv Sci (Weinh), 13(1):e05806(2026) [pubmed]

Keyword List

submitter keyword: Human, Cell, tRF-22, ESCC, LC-MS/MS

submitter keyword: Human, Cell, tRF-22, ESCC, LC-MS/MS

Contact List

Ling Pan
contact affiliation	Qilu Hospital of Shandong University
contact email	panling_1206@163.com
lab head
Xin Qin
contact affiliation	Qilu Hospital of Shandong University
contact email	qinxinsdu2018@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD057698
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD057698

PRIDE project URI

Repository Record List

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