PXD057674

PXD057674 is an original dataset announced via ProteomeXchange.

Title	Investigation of CL26 binding on AGPAT4 protein
Description	We have identified CL26 as a covalent inhibitor against AGPAT4, an aberrant protein complicated in hepatocellular carcinoma (HCC). CL26 treatment reversed HCC stemness and resistance to the first-line medication sorafenib. This experiment was conducted to investigate the covalent binding of CL26 onto AGPAT4 in vitro.
HostingRepository	PRIDE
AnnounceDate	2025-07-21
AnnouncementXML	Submission_2025-07-20_20:05:46.532.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tin Yan Koo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-08 09:03:21	ID requested
⏵ 1	2025-07-20 20:05:46	announced

Dataset with its publication pending

submitter keyword: Human, Liver, Shotgun proteomics

CHUNG, Clive Yik Sham
contact affiliation	School of Biomedical Sciences and Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
contact email	cyschung@hku.hk
lab head
Tin Yan Koo
contact affiliation	The University of Hong Kong
contact email	u3548650@connect.hku.hk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD057674
     1. Label: PRIDE project
     2. Name: Investigation of CL26 binding on AGPAT4 protein