PXD057650

PXD057650 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phosphoproteomic analysis of legumain deficient mice
Description	Asparagine endopeptidase (AEP), a cysteine proteinase found in plants and animals, plays a crucial role in regulating kidney homeostasis, immune response, and bone remodelling. It is dysregulated in cancer and neurodegenerative diseases. A study analysing protein phosphorylation in legumain knock-out mice revealed YBX1 phosphorylation on serine 102 as a key site, activating the NF-kB pathway and enhancing inflammation response in the kidney. The study also identified potential novel legumain substrates, providing insights into its role in cellular processes.
HostingRepository	MassIVE
AnnounceDate	2025-07-22
AnnouncementXML	Submission_2025-07-22_22:57:23.318.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tilen Sever
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	Phospho
Instrument	LTQ Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-08 00:37:15	ID requested
⏵ 1	2025-07-22 22:57:23	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Legumain, mouse, phosphorylation, proteomics, DatasetType:Proteomics

submitter keyword: Legumain, mouse, phosphorylation, proteomics, DatasetType:Proteomics

Contact List

Marko Fonovic
contact affiliation	Jozef Stefan Institute
contact email	marko.fonovic@ijs.si
lab head
Tilen Sever
contact affiliation	Jozef Stefan Institute
contact email	tilen.sever@ijs.si
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096338/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096338/