PXD057645

PXD057645 is an original dataset announced via ProteomeXchange.

Title	Role of PRMT5 in DNA damage response
Description	Protein arginine methyltransferase (PRMT5) has emerged as a crucial symmetric dimethylating enzyme involved in the methylation of a myriad of substrates critical for epigenetic regulation, DNA damage signalling, RNA splicing, and cell fate decision. Here we have uploaded the PRMT5 interactome with the nuclear and mitochondrial proteins. The Arginine methylation of rge proteins were evaluated for biological Function.
HostingRepository	PRIDE
AnnounceDate	2026-03-16
AnnouncementXML	Submission_2026-03-16_08:38:29.291.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Benu Brata Das
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-07 22:11:45	ID requested
⏵ 1	2026-03-16 08:38:30	announced

Bhattacharjee S, Das S, Chowdhury B, Das BB, PRMT5 in mitochondria regulates mtDNA stability through TFAM arginine methylation. Nat Commun, ():(2026) [pubmed]

10.1038/s41467-026-69676-7;

submitter keyword: mitochondrial homeostasis, post translational modification, PRMT5, mitochondrial biogenesis,TFAM, mtDNA damage

Benu Brata
contact affiliation	Professor Wellcome-Trust/ DBT India alliance fellow Head, Laboratory of Molecular Biology School of Biological Sciences Indian Association For The Cultivation Of Science
contact email	pcbbd@iacs.res.in
lab head
Benu Brata Das
contact affiliation	Laboratory of Molecular Biology, School of Biological Sciences, Indian Association for the Cultivation of Science, 2A & B, Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, India. Tel: +91 33 2473 4971
contact email	pcspc@iacs.res.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD057645

PRIDE project URI

• PRIDE
  1. PXD057645
     1. Label: PRIDE project
     2. Name: Role of PRMT5 in DNA damage response