PXD057614

PXD057614 is an original dataset announced via ProteomeXchange.

Title	Human Cerebrospinal Fluid HDL-like proteome from Alzheimer Disease patients
Description	Apolipoprotein (Apo) E4 is a key genetic risk factor for Alzheimer’s disease (AD). In the central nervous system, ApoE-containing high-density lipoprotein (HDL)-like particles transport glial cholesterol to neurons, playing a crucial role in neuronal membrane remodeling and maintenance of the myelin sheath. Despite this, the impact of HDL-like cholesterol trafficking on AD pathogenesis is not yet fully understood.The objective was to examine cholesterol transport via HDL-like particles in cerebrospinal fluid (CSF) of AD patients compared to control individuals. Additionally, we explored the ability of ApoE4-containing HDL to regulate the cholesterol efflux pathway in astrocytoma cells and facilitate cholesterol delivery to neurons.Mass spectrometry (MS) was used for a detailed analysis of the HDL-like proteome in AD patients and controls.
HostingRepository	PRIDE
AnnounceDate	2025-09-08
AnnouncementXML	Submission_2025-09-07_16:42:42.684.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Estefanía Núñez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-07 02:53:11	ID requested
⏵ 1	2025-09-07 16:42:43	announced

10.1016/j.jlr.2025.100865;

Borr, à, s C, Canyelles M, Santos D, Rotllan N, N, ú, ñ, ez E, V, á, zquez J, Maspoch D, Cano-Sarabia M, Zhao Q, Carmona-Iragui M, Sirisi S, Lle, ó A, Fortea J, Alcolea D, Blanco-Vaca F, Escol, à, -Gil JC, Tondo M, Cerebrospinal fluid lipoprotein-mediated cholesterol delivery to neurons is impaired in Alzheimer's disease and involves APOE4. J Lipid Res, 66(8):100865(2025) [pubmed]

submitter keyword: Human, AD, CSF, HDL

Jesús Vázquez
contact affiliation	Cardiovascular Proteomics, Centro Nacional de Investigaciones Cardiovasculares
contact email	enunez@cnic.es
lab head
Estefanía Núñez
contact affiliation	Centro Nacional de Investigaciones Cardiovasculares
contact email	enunez@cnic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD057614

PRIDE project URI

• PRIDE
  1. PXD057614
     1. Label: PRIDE project
     2. Name: Human Cerebrospinal Fluid HDL-like proteome from Alzheimer Disease patients