PXD057552

PXD057552 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Human coronavirus-229E infection alters the structure of host RNA processing complexes
Description	The purpose of this experiment was to evaluate the human host cellular response to wild-type human coronavirus strain 229E (HCoV-229E)(ncbitaxon:11137) infection. Sample data was obtained for mock and infected (MOI 3) immortalized human lung epithelial cells (A549), immortalized human lung fibroblasts cells (MRC5), and primary human airway epithelial cells from lung tissue, and processed for proteome expression analysis using Limited Proteolysis (LiP) methods for Tandem Mass Tag 16-Plex (TMT16) and global proteomic measurements. Sample data was acquired using a Q-Exactive HF-X mass spectrometer and data was processed and compiled using MaxQuant software (v1.6.17.0).
HostingRepository	MassIVE
AnnounceDate	2025-10-16
AnnouncementXML	Submission_2025-10-16_15:57:50.669.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matthew Monroe
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Acetyl; Carbamidomethyl
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-05 15:13:18	ID requested
⏵ 1	2025-10-16 15:57:51	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: host-pathogen interactions, human coronavirus 229E (HCoV-229E), limited proteolysis-based mass spectrometry (LiP-MS), protein structural changes, therapeutic targets, viral infections, DatasetType:Proteomics

submitter keyword: host-pathogen interactions, human coronavirus 229E (HCoV-229E), limited proteolysis-based mass spectrometry (LiP-MS), protein structural changes, therapeutic targets, viral infections, DatasetType:Proteomics

Contact List

John T. Melchior
contact affiliation	Pacific Northwest National Laboratory
contact email	john.melchior@pnnl.gov
lab head
Matthew Monroe
contact affiliation	Pacific Northwest National Laboratory
contact email	matthew.monroe@pnnl.gov
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096303/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096303/