PXD057447 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Elimination of intracellular microbes using combination therapy and unveiling survival mechanism of host cells upon Microbial Invasion |
| Description | Intracellular microbes are actively present in various tumor types in low biomass and play major role in metastasis. Eliminating intracellular microbes on a cellular level with precision remains a challenge for addressing this, we designed a screening pipeline to characterize intracellular microbes and their interaction with host cells. For that we used host and microbial in-vitro model cell line as HeLa and microbial strain as Escherichia coli 25922. To study dynamics of intracellular microbes we used antibiotics (ampicillin, roxithromycin, ciprofloxacin) and chemotherapy drugs (doxorubicin and cisplatin) as external environmental stress conditions. To effectively eliminate intracellular microbes Permutation Orthogonal Arrays (POA) approach was applied to acquire optimal drug combination regimen in dose and sequence of drugs which reduced 90-95% of intracellular microbial load. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-02 |
| AnnouncementXML | Submission_2026-03-01_18:54:41.346.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | 爽 张 |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Escherichia coli; NCBI TaxID: NEWT:562; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-02 05:29:45 | ID requested | |
| ⏵ 1 | 2026-03-01 18:54:42 | announced | |
Publication List
| 10.1016/j.ijantimicag.2025.107471; |
| Khan ZA, Song SS, Xu H, Ahmad M, Wang A, Abdullah A, Jiang L, Ding X, Elimination of intracellular microbes using drug combination therapy and unveiling survival mechanism of host cells upon microbial invasion. Int J Antimicrob Agents, 65(5):107471(2025) [pubmed] |
Keyword List
| submitter keyword: proteomics |
| mass spectrometry |
| DDA |
Contact List
| ZARA AHMAD KHAN |
|---|
| contact affiliation | Shanghai Jiao Tong University |
| contact email | khanzaraahmad@alumni.sjtu.edu.cn |
| lab head | |
| 爽 张 |
|---|
| contact affiliation | Shanghai Jiao Tong University |
| contact email | nocturne@sjtu.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD057447 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057447
- Label: PRIDE project
- Name: Elimination of intracellular microbes using combination therapy and unveiling survival mechanism of host cells upon Microbial Invasion
