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PXD057443

PXD057443 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe Adipose Tissue Knowledge Portal Integrates Clinical and Experimental Data to Provide Biological Insights
DescriptionWhite adipose tissue plays a pivotal role in energy storage and release, and disruptions in these processes, marked by transcriptional disturbances, are linked to cardiometabolic diseases. Consequently, many efforts have focused on understanding adipose tissue function through transcriptional analyses. However, the resulting data are scattered and lack a unified approach for exploration. To address this gap, we present the Adipose Tissue Knowledge Portal (ATportal; www.adiposetissue.org) where we have systematically collected, generated, re-analyzed, and integrated transcriptomic and proteomic data from diverse clinical cohorts, multiple adipose-residing cell types, and perturbation studies of human adipocytes. Using the ATportal, we identify genes associated with lipid turnover in clinical samples and test their function in a mini-depletion screen. Our data reveal that the tyrosine-kinase receptor TYRO3 acts as a positive regulator of hormone-stimulated lipolysis. Overall, our open-access framework allows integrative analyses and serves as a powerful discovery tool to uncover new aspects of adipose biology.
HostingRepositoryPRIDE
AnnounceDate2025-03-17
AnnouncementXMLSubmission_2025-03-17_10:08:59.077.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNatalie Krahmer
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-01 17:00:07ID requested
12025-03-17 10:08:59announced
Publication List
10.1016/J.CMET.2025.01.012;
Keyword List
submitter keyword: Adipose tissue, human
Contact List
Natalie Krahmer
contact affiliationHelmholtz Dibetes Center Mnich
contact emailnatalie.krahmer@helmholtz-munich.de
lab head
Natalie Krahmer
contact affiliationHelmholtz Center Munich
contact emailnatalie.krahmer@helmholtz-muenchen.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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