PXD057443

PXD057443 is an original dataset announced via ProteomeXchange.

Title	The Adipose Tissue Knowledge Portal Integrates Clinical and Experimental Data to Provide Biological Insights
Description	White adipose tissue plays a pivotal role in energy storage and release, and disruptions in these processes, marked by transcriptional disturbances, are linked to cardiometabolic diseases. Consequently, many efforts have focused on understanding adipose tissue function through transcriptional analyses. However, the resulting data are scattered and lack a unified approach for exploration. To address this gap, we present the Adipose Tissue Knowledge Portal (ATportal; www.adiposetissue.org) where we have systematically collected, generated, re-analyzed, and integrated transcriptomic and proteomic data from diverse clinical cohorts, multiple adipose-residing cell types, and perturbation studies of human adipocytes. Using the ATportal, we identify genes associated with lipid turnover in clinical samples and test their function in a mini-depletion screen. Our data reveal that the tyrosine-kinase receptor TYRO3 acts as a positive regulator of hormone-stimulated lipolysis. Overall, our open-access framework allows integrative analyses and serves as a powerful discovery tool to uncover new aspects of adipose biology.
HostingRepository	PRIDE
AnnounceDate	2025-03-17
AnnouncementXML	Submission_2025-03-17_10:08:59.077.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Natalie Krahmer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-01 17:00:07	ID requested
⏵ 1	2025-03-17 10:08:59	announced

10.1016/J.CMET.2025.01.012;

submitter keyword: Adipose tissue, human

Natalie Krahmer
contact affiliation	Helmholtz Dibetes Center Mnich
contact email	natalie.krahmer@helmholtz-munich.de
lab head
Natalie Krahmer
contact affiliation	Helmholtz Center Munich
contact email	natalie.krahmer@helmholtz-muenchen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD057443

PRIDE project URI

• PRIDE
  1. PXD057443
     1. Label: PRIDE project
     2. Name: The Adipose Tissue Knowledge Portal Integrates Clinical and Experimental Data to Provide Biological Insights