PXD057443 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The Adipose Tissue Knowledge Portal Integrates Clinical and Experimental Data to Provide Biological Insights |
Description | White adipose tissue plays a pivotal role in energy storage and release, and disruptions in these processes, marked by transcriptional disturbances, are linked to cardiometabolic diseases. Consequently, many efforts have focused on understanding adipose tissue function through transcriptional analyses. However, the resulting data are scattered and lack a unified approach for exploration. To address this gap, we present the Adipose Tissue Knowledge Portal (ATportal; www.adiposetissue.org) where we have systematically collected, generated, re-analyzed, and integrated transcriptomic and proteomic data from diverse clinical cohorts, multiple adipose-residing cell types, and perturbation studies of human adipocytes. Using the ATportal, we identify genes associated with lipid turnover in clinical samples and test their function in a mini-depletion screen. Our data reveal that the tyrosine-kinase receptor TYRO3 acts as a positive regulator of hormone-stimulated lipolysis. Overall, our open-access framework allows integrative analyses and serves as a powerful discovery tool to uncover new aspects of adipose biology. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-17 |
AnnouncementXML | Submission_2025-03-17_10:08:59.077.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Natalie Krahmer |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-11-01 17:00:07 | ID requested | |
⏵ 1 | 2025-03-17 10:08:59 | announced | |
Publication List
Keyword List
submitter keyword: Adipose tissue, human |
Contact List
Natalie Krahmer |
contact affiliation | Helmholtz Dibetes Center Mnich |
contact email | natalie.krahmer@helmholtz-munich.de |
lab head | |
Natalie Krahmer |
contact affiliation | Helmholtz Center Munich |
contact email | natalie.krahmer@helmholtz-muenchen.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD057443 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057443
- Label: PRIDE project
- Name: The Adipose Tissue Knowledge Portal Integrates Clinical and Experimental Data to Provide Biological Insights