PXD057427

PXD057427 is an original dataset announced via ProteomeXchange.

Title	Taurine inhibits apolipoprotein E4 aggregation
Description	ApoE4 is the first genetic risk factor for Alzheimer's disease. Its aberrant aggregation can be inhibited by tramiprosate (TMP) and its metabolite 3-sulfopropanoic acid (SPA), along with their impact on the transcription of genes, expression of proteins, and production of lipids. Taurine (TAU) is a close chemical analogue of TMP which has already proven beneficial effects against aging. Combining static light scattering, hydrogen-deuterium exchange mass spectrometry, molecular dynamics with analysis of Markov states, and investigation of cerebral organoids, we compare the effects of TMP, SPA, and TAU on ApoE4 aggregation, and organoid transcriptomics and proteomics. We found that TAU has a similar effect as SPA in inhibiting ApoE4 aggregation and correcting the pathophysiological phenotype of ApoE4 towards that of ApoE3 in cerebral organoids. These findings suggest that taurine may have potential as a therapeutic agent for Alzheimer's disease, particularly in individuals carrying the ApoE4/E4 genotype
HostingRepository	PRIDE
AnnounceDate	2026-07-09
AnnouncementXML	Submission_2026-07-09_08:49:03.164.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Naina Verma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Bruker Daltonics timsTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-01 05:51:36	ID requested
1	2026-07-09 08:46:45	announced
⏵ 2	2026-07-09 08:49:03	announced	2026-07-09: Updated project metadata.

10.1016/J.BIOPHA.2026.119395;

submitter keyword: Human, mass spectrometry, Alzheimer's desease, Parkinson's disease, HDX-MS

Prof. Lenka Hernychova
contact affiliation	RECAMO, Masaryk Memorial Cancer Institute Zluty Kopec, Brno, Czech Republic
contact email	lenka.hernychova@mou.cz
lab head
Naina Verma
contact affiliation	Masaryk Memorial Cancer Institute
contact email	naina.verma@mou.cz
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD057427
     1. Label: PRIDE project
     2. Name: Taurine inhibits apolipoprotein E4 aggregation