PXD057419

PXD057419 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of hippocampal tissue from adult CMTR1-cKO mice
Description	Eukaryotic mRNA is 5-end capped with m7 guanosine, forming the cap0 (m7GpppNpNp, N: any nucleotide). Cap methyltransferase (CMTR1) further catalyzes 2-O-ribose methylation of the first transcribed nucleotide (N1 2-O-Me) to produce the cap1 (m7GpppNmNp) structure in all eukaryotes except yeasts. To elucidate the molecular changes in the hippocampus caused by the deletion of CMTR1 in Emx1-lineage cells, hippocampal tissues from CMTR1-cWT and cKOEmx1 mice were processed for proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2025-08-29
AnnouncementXML	Submission_2025-08-29_02:46:21.021.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi-Shuian Huang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-31 23:54:24	ID requested
⏵ 1	2025-08-29 02:46:21	announced

10.1016/J.PNEUROBIO.2025.102802;

submitter keyword: LC-MS/MS, CMTR1

Dr. Yi-Shuian Huang
contact affiliation	Institute of Biomedical Sciences, Academia Sinica, Taiwan
contact email	yishuian@ibms.sinica.edu.tw
lab head
Yi-Shuian Huang
contact affiliation	Institute of Biomedical Sciences, Academia Sinica
contact email	n703yh@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD057419

PRIDE project URI

• PRIDE
  1. PXD057419
     1. Label: PRIDE project
     2. Name: Proteomic analysis of hippocampal tissue from adult CMTR1-cKO mice