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PXD057373

PXD057373 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMorpholino nicotinamide analogs of ponatinib, dual MNK, p70S6K inhibitors, display efficacy against lung and breast cancers
DescriptionGlobal and phosphoproteomic analysis to identify and characterize oncogenic pathways differentially regulated by the MNK/p70S6Ki, HSND80
HostingRepositoryPRIDE
AnnounceDate2025-03-27
AnnouncementXMLSubmission_2025-03-27_08:41:21.429.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRodrigo Mohallem
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-10-30 14:14:49ID requested
12025-03-27 08:41:22announced
Publication List
10.1016/j.bioorg.2025.108298;
Chaudhuri R, Dayal N, Kaiser J, Mohallem R, Brauer NR, Yeboah KS, Aryal UK, Sintim HO, Morpholino nicotinamide analogs of ponatinib, dual MNK, p70S6K inhibitors, display efficacy against lung and breast cancers. Bioorg Chem, 159():108298(2025) [pubmed]
Keyword List
submitter keyword: anticancer,kinase inhibitor, TNBC, small molecules, MNKi, NSCLC, p70S6Ki
Contact List
Herman O.
contact affiliationDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA Purdue Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, IN 47907, USA Purdue Institute for Cancer Research, Purdue University, 201 S. University Street, West Lafayette, IN 47907, USA
contact emailhsintim@purdue.edu
lab head
Rodrigo Mohallem
contact affiliationPurdue University
contact emailferreir@purdue.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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