PXD057373 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Morpholino nicotinamide analogs of ponatinib, dual MNK, p70S6K inhibitors, display efficacy against lung and breast cancers |
Description | Global and phosphoproteomic analysis to identify and characterize oncogenic pathways differentially regulated by the MNK/p70S6Ki, HSND80 |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-27 |
AnnouncementXML | Submission_2025-03-27_08:41:21.429.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Rodrigo Mohallem |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-10-30 14:14:49 | ID requested | |
⏵ 1 | 2025-03-27 08:41:22 | announced | |
Publication List
10.1016/j.bioorg.2025.108298; |
Chaudhuri R, Dayal N, Kaiser J, Mohallem R, Brauer NR, Yeboah KS, Aryal UK, Sintim HO, Morpholino nicotinamide analogs of ponatinib, dual MNK, p70S6K inhibitors, display efficacy against lung and breast cancers. Bioorg Chem, 159():108298(2025) [pubmed] |
Keyword List
submitter keyword: anticancer,kinase inhibitor, TNBC, small molecules, MNKi, NSCLC, p70S6Ki |
Contact List
Herman O. |
contact affiliation | Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA Purdue Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, IN 47907, USA Purdue Institute for Cancer Research, Purdue University, 201 S. University Street, West Lafayette, IN 47907, USA |
contact email | hsintim@purdue.edu |
lab head | |
Rodrigo Mohallem |
contact affiliation | Purdue University |
contact email | ferreir@purdue.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD057373 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057373
- Label: PRIDE project
- Name: Morpholino nicotinamide analogs of ponatinib, dual MNK, p70S6K inhibitors, display efficacy against lung and breast cancers