PXD057325

PXD057325 is an original dataset announced via ProteomeXchange.

Title	Effect of polypharmacy on the left ventricular proteome of mice across age and sex
Description	The use of polypharmacy (5 or more concurrent medications) is common in older patients, particularly those with cardiovascular diseases. However, polypharmacy is associated with adverse geriatric outcomes, including increased risks in fall and frailty. Both ageing and sex influence pharmacological response and cardiac physiology. The mechanistic intersect between age, sex, and drug-drug interaction is poorly understood. Previously, we have developed a polypharmacy murine model whereby young (4 months) and old (23 months) healthy C57BL/6JArc mice of both sexes were randomised to either polypharmacy or control. The polypharmacy regimen has a High Drug Burden Index (HDBI) and contains 3 medications with anticholinergic/sedative medications (oxybutynin, oxycodone, citalopram) along with cardiovascular medications (simvastatin and metoprolol). Medications were given at oral therapeutic doses. HDBI has clinically been demonstrated to be particularly associated with adverse geriatric outcomes. Here, we profiled the left ventricular (LV) proteome following 10 weeks of HDBI polypharmacy treatment along with age- and sex-matched controls.
HostingRepository	PRIDE
AnnounceDate	2025-06-02
AnnouncementXML	Submission_2025-06-01_18:32:42.612.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kevin Winardi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-29 20:24:02	ID requested
⏵ 1	2025-06-01 18:32:42	announced

10.1111/BPH.70082;

submitter keyword: heart, DIA,Mouse, pharmacology, sex, left ventricle, polypharmacy, age, LC-MS/MS

Prof Sarah N. Hilmer
contact affiliation	Laboratory of Ageing and Pharmacology, Kolling Institute, The University of Sydney
contact email	sarah.hilmer@sydney.edu.au
lab head
Kevin Winardi
contact affiliation	The University of Sydney, Kolling Institute
contact email	kevin.winardi@sydney.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD057325

PRIDE project URI

• PRIDE
  1. PXD057325
     1. Label: PRIDE project
     2. Name: Effect of polypharmacy on the left ventricular proteome of mice across age and sex