⮝ Full datasets listing
PXD057242
PXD057242 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Schizophrenia-linked AS3MTd2d3 Perturbs Cell Fate |
| Description | The neurodevelopmental theory of schizophrenia highlights the role of early brain development in the disorder's origins. Genome-wide association studies have linked schizophrenia to genetic variations in the AS3MT gene, particularly the AS3MTd2d3 isoform. To explore this connection, we created a transgenic mouse model (AS3MTd2d3-Tg) that expresses AS3MTd2d3 in cortical neural stem cells. These mice showed enlarged ventricles and impairments in sensorimotor gating and sociability. Single-cell and single-nucleus RNA sequencing of AS3MTd2d3-Tg brains revealed imbalances in cell fate and changes in excitatory neuron composition. AS3MTd2d3 was found to localize to the centrosome, disrupting mitotic spindle orientation and differentiation in the developing neocortex and organoids. Structural analysis indicated that exposed hydrophobic residues in AS3MTd2d3 are crucial for its pathogenic function. These findings may shed light on the early pathological features of schizophrenia. |
| HostingRepository | jPOST |
| AnnounceDate | 2025-10-28 |
| AnnouncementXML | Submission_2025-10-27_08:00:04.346.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | TRUONG THI MY NHUNG |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-28 01:09:59 | ID requested | |
| ⏵ 1 | 2025-10-27 08:00:04 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: AS3MTd2d3, Schizophrenia, Proteomics |
Contact List
| Sang Ki Park | |
|---|---|
| lab head | |
| TRUONG THI MY NHUNG | |
| contact affiliation | Pohang University of Science and Technology |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003437/ |
