PXD057241
PXD057241 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning |
| Description | Sepsis is a severe global health issue with high mortality rates, and sepsis-associated encephalopathy (SAE) further exacerbates this risk. While recent studies have shown the migration of gut immune cells to the lungs after sepsis, their impact on the central nervous system remains unclear. Our research demonstrates that sepsis could induce the migration of IL-7Rhigh CD8low γδ T17 cells from the small intestine to the meninges, where they secrete IL-17A, impairing mitochondrial function in microglia and activating the cGAS-STING-C1q pathway. This process is accompanied by inhibited ubiquitination of STING at the K150 site, resulting in STING accumulation and increased release of C1q-tagged hippocampal synapses, which are subsequently pruned by activated microglia. Importantly, 4-Octyl itaconate mitigates the excessive synaptic pruning by inhibiting γδ T17 cell migration and promoting STING ubiquitination, thereby alleviating SAE. Our findings reveal a novel mechanism of synaptic pruning by microglia via the cGAS-STING-C1q pathway, emphasize the critical role of gut-derived γδ T17 cell migration to the meninges in SAE, and highlight the importance of STING ubiquitination in modulating C1q-mediated excessive synaptic pruning. |
| HostingRepository | iProX |
| AnnounceDate | 2024-10-28 |
| AnnouncementXML | Submission_2024-10-27_23:40:57.920.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuming Wu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-27 23:40:41 | ID requested | |
| ⏵ 1 | 2024-10-27 23:40:58 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Sepsis-associated encephalopathy, "gut-brain" axis |
Contact List
| Jiancheng Zhang | |
|---|---|
| contact affiliation | Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | zhjcheng1@126.com |
| lab head | |
| Yuming Wu | |
| contact affiliation | Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | 18615711896@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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