PXD057183

PXD057183 is an original dataset announced via ProteomeXchange.

Title	Role of immune dysfunction in Moyamoya disease - LCM proteomics
Description	Moyamoya disease (MMD) is a rare and progressive cerebrovascular disorder characterized by the gradual stenosis (narrowing) and occlusion of critical intracranial arteries. The etiology of this disease is still unknown. Here we use Laser capture microdissection followed by shotgun proteomics to analyse the brain of a moyamoya patient. We found that phenotypic switching of VSMCs may be involved in the occlusion of the arteries. In addition, invasion of immune cells such as macrophages, in the occluding tissue were found, strengthening the hypothesis that an abberant immune response to infection may be one of the key mechanisms in MMD pathology.
HostingRepository	PRIDE
AnnounceDate	2025-10-20
AnnouncementXML	Submission_2025-10-20_05:42:53.622.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Patrick Willems
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF SCP

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-25 01:27:09	ID requested
⏵ 1	2025-10-20 05:42:54	announced

Dataset with its publication pending

submitter keyword: Moyamoya disease, intracranial artery, laser capture microdissection

Francis Impens
contact affiliation	VIB-UGent Center for Medical Biotechnology, Ghent, Belgium
contact email	Francis.Impens@UGent.be
lab head
Patrick Willems
contact affiliation	Ghent University
contact email	patwille.willems@ugent.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD057183

PRIDE project URI

• PRIDE
  1. PXD057183
     1. Label: PRIDE project
     2. Name: Role of immune dysfunction in Moyamoya disease - LCM proteomics