PXD057174

PXD057174 is an original dataset announced via ProteomeXchange.

Title	Mass spectrometry data of PBMCs after PBS/SEMA3G treatment
Description	The semaphorins encompass a substantial family of secreted and transmembrane glycoproteins, originally recognized as pivotal factors in guiding axonal growth during the development of neural circuitry. Recent studies have uncovered diverse functions of semaphorins in a wide array of immune responses, encompassing immune cell activation, differentiation, migration, and cell-cell interactions, contingent upon their transmembrane receptors and co-receptors within specific biological contexts. However, a comprehensive investigation exploring the role, mechanism, and the interplay between SEMA3G and tumor immune surveillance remains elusive.
HostingRepository	iProX
AnnounceDate	2024-10-25
AnnouncementXML	Submission_2025-02-01_09:22:16.853.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hao Chi
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-24 20:42:21	ID requested
⏵ 1	2025-02-01 09:22:17	announced

Chi H, Deng S, Xu K, Zhang Y, Song T, Yu J, Wang Y, Liu J, Zhang Y, Shi J, Wang Y, Xu J, SEMA3G-NRP1 Signaling Functions as an Immune Checkpoint That Enables Tumor Immune Evasion by Impairing T-cell Cytotoxicity. Cancer Res, 85(5):912-924(2025) [pubmed]

submitter keyword: immunotherapy, SEMA3G, T cells

Jie Xu
contact affiliation	Fudan University
contact email	jie_xu@fudan.edu.cn
lab head
Hao Chi
contact affiliation	Fudan University
contact email	chihao4201@163.com
dataset submitter

iProX dataset URI