PXD057140 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mass spectrometry analysis of proteins interacting with Fbxw7 in T cells |
Description | To elucidate how gut microbiota (GM) downregulated Fbxw7, we treated CD4+ T cells with GM-lysates and pulled down Fbxw7 in the cell lysates. Then, the precipitated proteins were analyzed by mass spectrometry, and eight E3 ligases were revealed to interact with Fbxw7. |
HostingRepository | PRIDE |
AnnounceDate | 2025-04-16 |
AnnouncementXML | Submission_2025-04-15_19:34:19.552.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD057140 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | peihan wu |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-10-24 02:26:10 | ID requested | |
⏵ 1 | 2025-04-15 19:34:20 | announced | |
Publication List
Shen Y, Ma Z, Wang H, Chen Y, Fang Y, Apetoh L, Zhang G, He F, Xie S, Guo J, Cao S, Li H, Wang Q, Wang J, Xu J, Cai Z, A. faecalis induces intestinal T helper 17 cells by promoting E3 ubiquitin ligase Trim21-mediated E3 ubiquitin ligase Fbxw7 degradation. Immunity, ():(2025) [pubmed] |
10.1016/j.immuni.2025.03.008; |
10.6019/PXD057140; |
Keyword List
submitter keyword: Fbxw7 |
Trim21 |
TH17 cells |
Gut microbiota |
Contact List
Zhijian Cai |
contact affiliation | Institute of Immunology and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China |
contact email | caizj@zju.edu.cn |
lab head | |
peihan wu |
contact affiliation | Westlake University |
contact email | wupeihan@westlake.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD057140 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057140
- Label: PRIDE project
- Name: Mass spectrometry analysis of proteins interacting with Fbxw7 in T cells