PXD057140

PXD057140 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mass spectrometry analysis of proteins interacting with Fbxw7 in T cells
Description	To elucidate how gut microbiota (GM) downregulated Fbxw7, we treated CD4+ T cells with GM-lysates and pulled down Fbxw7 in the cell lysates. Then, the precipitated proteins were analyzed by mass spectrometry, and eight E3 ligases were revealed to interact with Fbxw7.
HostingRepository	PRIDE
AnnounceDate	2025-04-16
AnnouncementXML	Submission_2025-04-15_19:34:19.552.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD057140
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	peihan wu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-24 02:26:10	ID requested
⏵ 1	2025-04-15 19:34:20	announced

Publication List

Shen Y, Ma Z, Wang H, Chen Y, Fang Y, Apetoh L, Zhang G, He F, Xie S, Guo J, Cao S, Li H, Wang Q, Wang J, Xu J, Cai Z, Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation. Immunity, 58(6):1469-1483.e8(2025) [pubmed]
10.1016/j.immuni.2025.03.008;
10.6019/PXD057140;

Shen Y, Ma Z, Wang H, Chen Y, Fang Y, Apetoh L, Zhang G, He F, Xie S, Guo J, Cao S, Li H, Wang Q, Wang J, Xu J, Cai Z, Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation. Immunity, 58(6):1469-1483.e8(2025) [pubmed]

10.1016/j.immuni.2025.03.008;

10.6019/PXD057140;

Keyword List

submitter keyword: Fbxw7
Trim21
TH17 cells
Gut microbiota

submitter keyword: Fbxw7

Trim21

TH17 cells

Gut microbiota

Contact List

Zhijian Cai
contact affiliation	Institute of Immunology and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
contact email	caizj@zju.edu.cn
lab head
peihan wu
contact affiliation	Westlake University
contact email	wupeihan@westlake.edu.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD057140
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD057140

PRIDE project URI

Repository Record List

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