PXD057128
PXD057128 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Probing the Role of O-GlcNAcylation in Modulating Protein-DNA Interactions: Insights from a Proteomic Transcription Factor Response Element-Based Pulldown Screening Approach |
Description | O-linked β-N-acetylglucosamine (O-GlcNAc), a critical post-translational modification (PTM) predominantly found in the nucleus, plays a substantial role in regulating gene expression by modulating transcription factors (TFs) activity. Herein, by utilizing a pulldown screening approach termed as tandem array of transcription factors response elements (catTFREs), we unravel the profound impact of fluctuating levels of O-GlcNAcylation on the DNA binding efficiency of endogenous TFs. The proteins were enriched for label-free quantitative proteomics by LC-MS/MS. |
HostingRepository | iProX |
AnnounceDate | 2024-10-24 |
AnnouncementXML | Submission_2024-10-23_20:10:48.546.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yubo Liu |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-10-23 20:10:26 | ID requested | |
⏵ 1 | 2024-10-23 20:10:48 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: O-GlcNAc, transcription factors, DNA-protein interaction |
Contact List
Yubo Liu | |
---|---|
contact affiliation | Dalian University of Technology |
contact email | liuyubo@dlut.edu.cn |
lab head | |
Yubo Liu | |
contact affiliation | Dalian University of Technology |
contact email | liuyubo@dlut.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |