PXD057060

PXD057060 is an original dataset announced via ProteomeXchange.

Title	Age-dependent changes of honeybee worker gut and brains
Description	In honeybees, division of labour is a key feature, with age-related behavioural transitions being closely associated with molecular changes in the brain, gut, and microbiota. In this study, we integrated omics approaches to describe the global metabolomic and proteomic shifts in honeybee workers and their microbiota throughout their lives to better understand their contribution to behavioural responses and modulation. Through the use of age-controlled worker bees, the obtained results indicate transport of amino acids between the gut and brain, potentially influencing functional pathways and behavioural phenotypes. Our results demonstrate that altered pathway abundances may be due to energy expenditure, task differentiation and age of onset of foraging. Specific functional pathways in brain, gut and bacterial proteins were found to be up- or downregulated depending on the age or task of the workers. Overall, our findings provide new insights toward developing potential biomarkers for evaluation of different functional changes related to various environmental stressors.
HostingRepository	PRIDE
AnnounceDate	2026-02-27
AnnouncementXML	Submission_2026-02-27_11:34:16.405.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Cassandra Uthoff
SpeciesList	scientific name: Apis mellifera (Honeybee); NCBI TaxID: NEWT:7460;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-22 09:25:31	ID requested
⏵ 1	2026-02-27 11:34:16	announced

10.1016/J.JARE.2025.07.045;

submitter keyword: Age-dependent changes of honeybee worker gut and brains

Nico Jehmlich
contact affiliation	Department of Molecular Toxicology, Helmholtz Centre for Environmental Research - UFZ GmbH, Leipzig, Germany
contact email	nico.jehmlich@ufz.de
lab head
Cassandra Uthoff
contact affiliation	Helmholtz Centre for Environmental Research GmbH - UFZ
contact email	cassandra.uthoff@ufz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD057060

PRIDE project URI

• PRIDE
  1. PXD057060
     1. Label: PRIDE project
     2. Name: Age-dependent changes of honeybee worker gut and brains