PXD057058

PXD057058 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of mice pancreatic islet fed a high fat simple carbohydrate diet
Description	This study aims to elucidate the molecular mechanisms linking dietary stress from a high-fat simple carbohydrate (HFSC) diet to an elevated risk of pancreatic cancer. Using label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS), we performed a comprehensive proteomic analysis of collagenase-digested pancreatic islets from HFSC-fed mice. The study identified a significant upregulation and downregulation of 33 and 34 proteins respectively in HFSC group compared to the control group. The results revealed substantial alterations in the expression of proteins involved in key biological processes such as metabolic stress, protein synthesis, and endoplasmic reticulum (ER) stress, all of which are crucial for maintaining cellular homeostasis under dietary stress. Notably, the study identified several potential biomarkers, including MANF, VCP, HYOU1, and PRDX1, which are intricately linked to pancreatic function and the progression of cancer. These biomarkers play pivotal roles in managing cellular stress responses, protein folding, and metabolic regulation, offering insights into how a HFSC diet contributes to pancreatic carcinogenesis. This research highlights the significant impact of dietary factors on pancreatic cancer development and underscores the potential of these biomarkers as therapeutic targets for early detection and treatment, ultimately aiming to improve patient outcomes in PDAC.
HostingRepository	PRIDE
AnnounceDate	2026-04-22
AnnouncementXML	Submission_2026-04-22_06:43:45.433.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD057058
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Vijayalakshmi Gangadhara
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-22 08:43:25	ID requested
1	2026-04-22 06:34:52	announced
⏵ 2	2026-04-22 06:43:45	announced	2026-04-22: Updated project metadata.

10.6019/PXD057058;

submitter keyword: None

Asha Abraham
contact affiliation	Department of Biotechnology St Aloysius (Deemed to be University) Mangalore – 575 003, Karnataka, India.
contact email	drashaabraham@staloysius.edu.in
lab head
Vijayalakshmi Gangadhara
contact affiliation	St Aloysius (Deemed to be University), Mangaluru
contact email	vijayalakshmi@staloysius.edu.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD057058

PRIDE project URI

• PRIDE
  1. PXD057058
     1. Label: PRIDE project
     2. Name: Proteomic analysis of mice pancreatic islet fed a high fat simple carbohydrate diet