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PXD057039

PXD057039 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe High-Intensity Focused Ultrasound combined with IL-2 to activate the JAK-STAT signaling pathway for treating breast cancer
DescriptionIn our study, we applied thermal High-Intensity Focused Ultrasound (HIFU) and mechanical HIFU for the treatment of breast cancer in murine models. This approach led to a notable increase in IL2RB expression among CD8+ T cells within the tumor microenvironment, suggesting a potential immunomodulatory effect. Further investigation revealed that this upregulation was associated with the activation of the JAK-STAT signaling pathway, a key mediator of immune responses. Building on these findings, we then explored the synergistic potential of combining IL-2 with HIFU. Our results indicated that this combined therapeutic strategy yielded significantly enhanced tumor regression in mouse models of breast cancer, outperforming the effects observed with either modality alone. This suggests that the integration of HIFU with IL-2 may offer a promising avenue for improving breast cancer treatment outcomes.
HostingRepositoryiProX
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2025-06-03_20:11:19.466.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJiangbei Yuan
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-10-21 21:41:51ID requested
12025-06-03 20:11:19announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: T-HIFU, M-HIFU, Il2rb, IL-2, Jak1, Jak3, 4T1 cell
Contact List
Jiangbei Yuan
contact affiliationZhejiang Provincial People's Hospital and Chongqing University Cancer Hospital
contact emailyuanjiangbei@163.com
lab head
Jiangbei Yuan
contact affiliationZhejiang Provincial People's Hospital
contact emailyuanjiangbei@163.com
dataset submitter
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