PXD057039
PXD057039 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The High-Intensity Focused Ultrasound combined with IL-2 to activate the JAK-STAT signaling pathway for treating breast cancer |
| Description | In our study, we applied thermal High-Intensity Focused Ultrasound (HIFU) and mechanical HIFU for the treatment of breast cancer in murine models. This approach led to a notable increase in IL2RB expression among CD8+ T cells within the tumor microenvironment, suggesting a potential immunomodulatory effect. Further investigation revealed that this upregulation was associated with the activation of the JAK-STAT signaling pathway, a key mediator of immune responses. Building on these findings, we then explored the synergistic potential of combining IL-2 with HIFU. Our results indicated that this combined therapeutic strategy yielded significantly enhanced tumor regression in mouse models of breast cancer, outperforming the effects observed with either modality alone. This suggests that the integration of HIFU with IL-2 may offer a promising avenue for improving breast cancer treatment outcomes. |
| HostingRepository | iProX |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2025-06-03_20:11:19.466.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiangbei Yuan |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-21 21:41:51 | ID requested | |
| ⏵ 1 | 2025-06-03 20:11:19 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: T-HIFU, M-HIFU, Il2rb, IL-2, Jak1, Jak3, 4T1 cell |
Contact List
| Jiangbei Yuan | |
|---|---|
| contact affiliation | Zhejiang Provincial People's Hospital and Chongqing University Cancer Hospital |
| contact email | yuanjiangbei@163.com |
| lab head | |
| Jiangbei Yuan | |
| contact affiliation | Zhejiang Provincial People's Hospital |
| contact email | yuanjiangbei@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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