PXD057038

PXD057038 is an original dataset announced via ProteomeXchange.

Title	PBP inactivation and OXA treatment resulted in altered protein compositions of Staphylococcal membrane vesicles
Description	The engineered Staphylococcus aureus strain RN4220Δagr/EDⅢ was treated with 1/4 MIC of Oxacillin (OXA), or used to construct pbp3 and pbp4 gene mutant strain. Then, the membrane vesicles (MVs) of parent strain (ΔagrMVs), OXA-treated strain (Δagr/OXAMVs), and pbp3/pbp4 mutants (Δagr/OXAMVs) were harvested by density gradient centrifugation. The protein compositions of each MV sample were quantitated by using BCA Protein Assay Kit.
HostingRepository	iProX
AnnounceDate	2024-10-21
AnnouncementXML	Submission_2025-08-21_20:29:31.680.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaonan Huang
SpeciesList	scientific name: Staphylococcus aureus subsp. aureus RN4220; NCBI TaxID: 561307;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-21 21:39:17	ID requested
1	2024-10-21 21:39:42	announced
2	2025-08-21 19:09:00	announced	2025-08-22: Add info.
⏵ 3	2025-08-21 20:29:32	announced	2025-08-22: Add info. 2025-08-22: Add info.

Huang X, Hu Z, Shang W, Chen J, Hu Q, Zhou Y, Ding R, Yin J, Li M, Liu H, Dou J, Peng H, Rao Y, Liu L, Wang Y, Tan L, Yang Y, Wu J, Xiao C, Yang Y, Rao X, Beta-Lactam Antibiotics Promote Extracellular Vesicle Production of Staphylococcus aureus Through ROS-Mediated Lipid Metabolic Reprogramming. J Extracell Vesicles, 14(5):e70077(2025) [pubmed]

submitter keyword: S.aureus MVs

Xiancai Rao
contact affiliation	Army Medical University
contact email	raoxiancai@126.com
lab head
Xiaonan Huang
contact affiliation	Army Medical University
contact email	1251585584@qq.com
dataset submitter

iProX dataset URI